DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation (Q21146396)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

title

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

Parkinsonism associated deglycase

4 January 2020

main subject

molecular chaperones

0 references

1 reference

GOA release 2020-03-11

Synuclein alpha

1 reference

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

3

Cecile Martinat

Cecile

Martinat

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Shoshana Shendelman

1

Shoshana

Shendelman

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Alan Jonason

series ordinal

2

author given names

Alan

author last names

Jonason

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Thomas Leete

series ordinal

4

author given names

Thomas

author last names

Leete

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Asa Abeliovich

series ordinal

5

author given names

Asa

author last names

Abeliovich

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

language of work or name

English

0 references

publication date

5 October 2004

1 reference

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4 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

volume

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

page(s)

e362

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

4 January 2020

copyright license

start time

5 October 2004

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

1 reference

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DJ-1 has a role in antioxidative stress to prevent cell death

19 March 2017

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Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

19 March 2017

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

19 March 2017

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Effects of Charcot-Marie-Tooth-linked mutations of the neurofilament light subunit on intermediate filament formation

19 March 2017

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Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain

19 March 2017

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Crystal structure of DJ-1/RS and implication on familial Parkinson's disease

19 March 2017

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The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

19 March 2017

1 reference

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The crystal structure of DJ-1, a protein related to male fertility and Parkinson's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Crystal structure of human DJ-1, a protein associated with early onset Parkinson's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Crystal structure of an intracellular protease from Pyrococcus horikoshii at 2-A resolution

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Alpha-synuclein in Lewy bodies

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Parallel and comparative analysis of the proteome and transcriptome of sorbic acid-stressed Saccharomyces cerevisiae.

19 March 2017

1 reference

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L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat

19 March 2017

1 reference

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Structure and properties of small heat shock proteins (sHsp) and their interaction with cytoskeleton proteins

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

19 March 2017

https://api.crossref.org/works/10.1371%2FJOURNAL.PBIO.0020362

7 January 2021

inferred from DOI database lookup

DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Parkinson's disease: mechanisms and models

19 March 2017

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Oxidative stress in Parkinson's disease

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Crystallization and preliminary crystallographic analysis of DJ-1, a protein associated with male fertility and parkinsonism

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Structural composition of betaI- and betaII-proteins

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Hsp31, the Escherichia coli yedU gene product, is a molecular chaperone whose activity is inhibited by ATP at high temperatures.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Oxidatively modified proteins in aging and disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Etiology and pathogenesis of Parkinson's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Chaperone activity with a redox switch

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Filamentous alpha-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Characterization of the Escherichia coli YedU protein as a molecular chaperone

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Formation and removal of alpha-synuclein aggregates in cells exposed to mitochondrial inhibitors

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=521177

The C-terminal domain of HPII catalase is a member of the type I glutamine amidotransferase superfamily

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15502874

12 December 2020

inferred from PubMed ID database lookup

Hydroperoxidase II of Escherichia coli exhibits enhanced resistance to proteolytic cleavage compared to other catalases

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15502874

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/15502874

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PBIO.0020362

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15502874%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

15502874

2 references