Interleukin 1 receptor associated kinase 1 (Q21173372)

Protein kinase-like domain superfamily

1 reference

Death-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Interleukin-1 receptor-associated kinase 1, death domain, protein family

1 reference

Death domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Identification and characterization of murine IRAK-M

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

heat shock protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

protein homodimerization activity

NF-kappaB-inducing kinase activity

1 reference

8 April 2019

IRAK: a kinase associated with the interleukin-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

protein binding

17 references

8 April 2019

An inflammatory bowel disease-risk variant in INAVA decreases pattern recognition receptor-induced outcomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Characterization of Pellino2, a substrate of IRAK1 and IRAK4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

protein heterodimerization activity

1 reference

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

5 references

16 July 2018

16 July 2018

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

16 July 2018

16 July 2018

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

protein serine/threonine kinase activity

EXP

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

6 references

1 January 2018

1 January 2018

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

1 January 2018

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

1 January 2018

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

protein serine/threonine kinase activity

EXP

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

EXP

cell component

membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

1 reference

16 July 2018

endosome membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

interleukin-1 receptor complex

1 reference

8 April 2019

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

cellular response to heat

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

response to interleukin-1

1 reference

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

positive regulation of MAP kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

regulation of cytokine-mediated signaling pathway

1 reference

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

cytokine-mediated signaling pathway

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

immune system process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

human ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

negative regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

activation of NF-kappaB-inducing kinase activity

1 reference

8 April 2019

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

toll-like receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

positive regulation of transcription, DNA-templated

1 reference

8 April 2019

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

protein phosphorylation

response to lipopolysaccharide

1 reference

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

transmembrane receptor protein serine/threonine kinase signaling pathway

1 reference

8 April 2019

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

protein complex oligomerization

1 reference

8 April 2019

The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

protein autophosphorylation

IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Identification and characterization of murine IRAK-M

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

toll-like receptor 9 signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

cellular response to lipopolysaccharide

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

negative regulation of NF-kappaB transcription factor activity

1 reference

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

nucleotide-binding oligomerization domain containing signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

positive regulation of type I interferon production

1 reference

8 April 2019

HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

cellular response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

signal transduction

IRAK: a kinase associated with the interleukin-1 receptor

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

toll-like receptor 4 signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

toll-like receptor 2 signaling pathway

1 reference

10 September 2018

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

innate immune response

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

1 reference

10 September 2018

type I interferon signaling pathway

1 reference

8 April 2019

HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

8 April 2019

interleukin-1-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

3 references

16 July 2018

16 July 2018

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51617&geneProductId=UniProtKB:P51617

16 July 2018

intracellular signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

positive regulation of I-kappaB kinase/NF-kappaB signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

3 references

8 April 2019

8 April 2019

The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

positive regulation of NF-kappaB transcription factor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

3 references

8 April 2019

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

interleukin-1-mediated signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

4 references

8 April 2019

8 April 2019

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

positive regulation of leukocyte adhesion to vascular endothelial cell

1 reference

8 April 2019

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51617

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

serine/threonine-protein kinase, active site

1 reference

Interleukin-1 receptor-associated kinase 1, death domain

1 reference