G protein-coupled receptor 37 (Q21204205)

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mammalian protein found in Homo sapiens

PAELR
endothelin B receptor-like protein 1
G-protein coupled receptor 37
probable G-protein coupled receptor 37
Parkin-associated endothelin receptor-like receptor
GPR37
G protein-coupled receptor 37 (endothelin receptor type B-like)
ETBR-LP-1
prosaposin receptor GPR37

Language	Label	Description	Also known as
English	G protein-coupled receptor 37	mammalian protein found in Homo sapiens	PAELR endothelin B receptor-like protein 1 G-protein coupled receptor 37 probable G-protein coupled receptor 37 Parkin-associated endothelin receptor-like receptor GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) ETBR-LP-1 prosaposin receptor GPR37

Statements

1 reference

13 November 2019

UniProt protein ID

G protein-coupled receptor 37 orphan

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15354

G protein-coupled receptor

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

G protein-coupled peptide receptor activity

determination method or standard

1 reference

8 April 2019

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

G protein-coupled receptor activity

determination method or standard

heat shock protein binding

determination method or standard

1 reference

9 May 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

prosaposin receptor activity

determination method or standard

1 reference

8 April 2019

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

peptide binding

determination method or standard

1 reference

9 May 2019

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

signal transducer activity

determination method or standard

1 reference

31 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15354&geneProductId=UniProtKB:O15354

determination method or standard

Hsp70 protein binding

determination method or standard

1 reference

9 May 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

protein binding

determination method or standard

3 references

9 May 2019

A Product of the Human Gene Adjacent to parkin Is a Component of Lewy Bodies and Suppresses Pael Receptor-induced Cell Death

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

Systematic protein-protein interaction mapping for clinically relevant human GPCRs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

ubiquitin protein ligase binding

determination method or standard

3 references

9 May 2019

A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

G protein-coupled peptide receptor activity

determination method or standard

prosaposin receptor activity

determination method or standard

endoplasmic reticulum membrane

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

ubiquitin ligase complex

determination method or standard

1 reference

9 May 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

receptor complex

determination method or standard

1 reference

8 April 2019

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

plasma membrane

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

8 April 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

8 April 2019

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

9 May 2019

A novel endothelin receptor type-B-like gene enriched in the brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

plasma membrane

determination method or standard

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

biological process

G protein-coupled receptor signaling pathway

determination method or standard

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

A novel endothelin receptor type-B-like gene enriched in the brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

determination method or standard

1 reference

8 April 2019

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

dopamine biosynthetic process

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

locomotion involved in locomotory behavior

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

signal transduction

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

positive regulation of dopamine metabolic process

determination method or standard

1 reference

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

determination method or standard

positive regulation of MAPK cascade

determination method or standard

3 references

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15354

determination method or standard

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15354

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000306449

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000306449

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

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Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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