Inositol 1,4,5-trisphosphate receptor 1 (Q21495559)

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mammalian protein found in Mus musculus
  • inositol 1,4,5-trisphosphate receptor type 1
  • InsP3R1
  • Purkinje cell protein 1
  • Itpr1
  • IP3 receptor
  • type 1 inositol 1,4,5-trisphosphate receptor
  • type 1 InsP3 receptor
  • inositol 1,4,5-trisphosphate-binding protein P400
  • InsP>3<R type I
  • opisthotonus
  • IP3 receptor isoform 1
  • IP3R 1
  • protein PCD-6
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Language Label Description Also known as
English
Inositol 1,4,5-trisphosphate receptor 1
mammalian protein found in Mus musculus
  • inositol 1,4,5-trisphosphate receptor type 1
  • InsP3R1
  • Purkinje cell protein 1
  • Itpr1
  • IP3 receptor
  • type 1 inositol 1,4,5-trisphosphate receptor
  • type 1 InsP3 receptor
  • inositol 1,4,5-trisphosphate-binding protein P400
  • InsP>3<R type I
  • opisthotonus
  • IP3 receptor isoform 1
  • IP3R 1
  • protein PCD-6

Statements

molecular function
protein binding
determination method or standard
IPI
16 references
retrieved
14 February 2019
stated in
The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage
GOA
curator
UniProt
UniProt protein ID
P11881
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors
GOA
curator
UniProt
UniProt protein ID
P11881
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice
GOA
curator
UniProt
UniProt protein ID
P11881
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Stable expression and function of the inositol 1,4,5-triphosphate receptor requires palmitoylation by a DHHC6/selenoprotein K complex
GOA
curator
UniProt
UniProt protein ID
P11881
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Inositol 1, 4, 5-trisphosphate receptor interacts with the SNARE domain of syntaxin 1B
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Carbonic anhydrase-related protein is a novel binding protein for inositol 1,4,5-trisphosphate receptor type 1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Signaling complex formation of phospholipase Cbeta4 with metabotropic glutamate receptor type 1alpha and 1,4,5-trisphosphate receptor at the perisynapse and endoplasmic reticulum in the mouse brain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
retrieved
14 February 2019
stated in
Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IPI
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
determination method or standard
IDA
IEA
ISO
TAS
5 references
retrieved
24 April 2018
stated in
The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881
determination method or standard
TAS
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881
determination method or standard
ISO
retrieved
24 April 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881
determination method or standard
IEA
retrieved
24 April 2018
stated in
Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening
GOA
curator
UniProt
UniProt protein ID
P11881
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881
determination method or standard
IDA
retrieved
24 April 2018
stated in
Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P11881&geneProductId=UniProtKB:P11881
determination method or standard
IDA
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
determination method or standard
IBA
IDA
IEA
ISO
TAS
6 references
retrieved
14 February 2019
stated in
The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
TAS
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IEA
retrieved
14 February 2019
stated in
Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening
GOA
curator
UniProt
UniProt protein ID
P11881
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IDA
retrieved
14 February 2019
stated in
Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IDA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11881
determination method or standard
IBA
cell component
biological process

Identifiers

RefSeq protein ID
 
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