Calpain 3 (Q21497189)

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mammalian protein found in Mus musculus

calpain L3
CANP 3
calpain-3
skeletal muscle specific calpain p94
Capn3
muscle-specific calcium-activated neutral protease 3
calpain p94
calcium-activated neutral proteinase 3

Language	Label	Description	Also known as
English	Calpain 3	mammalian protein found in Mus musculus	calpain L3 CANP 3 calpain-3 skeletal muscle specific calpain p94 Capn3 muscle-specific calcium-activated neutral protease 3 calpain p94 calcium-activated neutral proteinase 3

Statements

1 reference

10 April 2019

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

Calpain large subunit, domain III superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

Papain-like cysteine peptidase superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase C2, calpain, large subunit, domain III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase C2, calpain, domain III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Calpain subdomain III, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase C2, calpain, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Cysteine peptidase, cysteine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

EF-Hand 1, calcium-binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

10 April 2019

UniProt protein ID

1 reference

10 April 2019

UniProt protein ID

molecular function

cysteine-type peptidase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

sodium ion binding

determination method or standard

1 reference

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

peptidase activity

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

catalytic activity

determination method or standard

protein binding

determination method or standard

3 references

8 April 2019

Dysferlin interacts with tubulin and microtubules in mouse skeletal muscle

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

molecular adaptor activity

determination method or standard

structural constituent of muscle

determination method or standard

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

ligase regulator activity

determination method or standard

calcium-dependent cysteine-type endopeptidase activity

determination method or standard

3 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

signaling receptor binding

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

calcium-dependent cysteine-type endopeptidase activity

determination method or standard

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

6 references

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

protein-containing complex

determination method or standard

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

7 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

biological process

muscle structure development

determination method or standard

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

cellular response to calcium ion

determination method or standard

1 reference

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

protein localization to membrane

determination method or standard

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

negative regulation of protein sumoylation

determination method or standard

positive regulation of satellite cell activation involved in skeletal muscle regeneration

determination method or standard

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

self proteolysis

determination method or standard

negative regulation of apoptotic process

determination method or standard

3 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

positive regulation of release of sequestered calcium ion into cytosol

determination method or standard

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

6 references

16 July 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

16 July 2018

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

negative regulation of skeletal muscle cell differentiation

determination method or standard

1 reference

16 July 2018

Rbfox1 downregulation and altered calpain 3 splicing by FRG1 in a mouse model of Facioscapulohumeral muscular dystrophy (FSHD)

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

G1 to G0 transition involved in cell differentiation

determination method or standard

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

cellular response to salt stress

determination method or standard

1 reference

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

myofibril assembly

determination method or standard

1 reference

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

regulation of myoblast differentiation

determination method or standard

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

positive regulation of proteolysis

determination method or standard

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

regulation of catalytic activity

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

1 reference

8 April 2019

Down-regulation of MyoD by calpain 3 promotes generation of reserve cells in C2C12 myoblasts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

3 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

programmed cell death

determination method or standard

1 reference

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

protein-containing complex assembly

determination method or standard

1 reference

8 April 2019

Novel role of calpain-3 in the triad-associated protein complex regulating calcium release in skeletal muscle

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

sodium-dependent self proteolysis

determination method or standard

1 reference

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

protein catabolic process

determination method or standard

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

protein destabilization

determination method or standard

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q64691&geneProductId=UniProtKB:Q64691

determination method or standard

determination method or standard

7 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Skeletal muscle-specific calpain is an intracellular Na+-dependent protease

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Null mutation of calpain 3 (p94) in mice causes abnormal sarcomere formation in vivo and in vitro

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

negative regulation of apoptotic process

determination method or standard

4 references

8 April 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

NF-kappaB-dependent expression of the antiapoptotic factor c-FLIP is regulated by calpain 3, the protein involved in limb-girdle muscular dystrophy type 2A

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q64691

determination method or standard

calcium-dependent self proteolysis

determination method or standard

Peptidase C2, calpain, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

Peptidase C2, calpain, large subunit, domain III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

EF-hand 1, calcium-binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

Peptidase C2, calpain, domain III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

Cysteine peptidase, cysteine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

Calpain subdomain III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q64691

Identifiers

RefSeq protein ID

1 reference

18 March 2019

1 reference

18 March 2019

1 reference

18 March 2019

UniProt protein ID

1 reference

10 April 2019

UniProt protein ID

Ensembl protein ID

ENSMUSP00000028749

1 reference

ensembl Release 96

Ensembl protein ID

ENSMUSP00000028749

ENSMUSP00000106349

1 reference

ensembl Release 96

Ensembl protein ID

ENSMUSP00000106349

ENSMUSP00000028748

1 reference

ensembl Release 96

Ensembl protein ID

ENSMUSP00000028748

ENSMUSP00000087482

1 reference

ensembl Release 96

Ensembl protein ID

ENSMUSP00000087482

ENSMUSP00000106344

1 reference

ensembl Release 96

Ensembl protein ID

ENSMUSP00000106344

ENSMUSP00000106347

1 reference

ensembl Release 96

Ensembl protein ID

ENSMUSP00000106347

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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