Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (Q21498207)

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mammalian protein found in Mus musculus

T-cell early activation protein
TEA
Slc7a2
cationic amino acid transporter 2
solute carrier family 7 member 2
20.5
low affinity cationic amino acid transporter 2
cationic amino acid transporter 2A
amino acid transporter, cationic 2 (low affinity)
cationic amino acid transporter 2B

Language	Label	Description	Also known as
English	Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	mammalian protein found in Mus musculus	T-cell early activation protein TEA Slc7a2 cationic amino acid transporter 2 solute carrier family 7 member 2 20.5 low affinity cationic amino acid transporter 2 cationic amino acid transporter 2A amino acid transporter, cationic 2 (low affinity) cationic amino acid transporter 2B

Statements

1 reference

25 May 2022

UniProt protein ID

Cationic amino acid transport permease

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18581

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Cationic amino acid transporter, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

high-affinity lysine transmembrane transporter activity

determination method

1 reference

24 April 2018

Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18581&geneProductId=UniProtKB:P18581

determination method

low-affinity L-arginine transmembrane transporter activity

determination method

L-arginine transmembrane transporter activity

determination method

1 reference

14 February 2019

CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

high-affinity L-arginine transmembrane transporter activity

determination method

1 reference

24 April 2018

Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18581&geneProductId=UniProtKB:P18581

determination method

L-ornithine transmembrane transporter activity

determination method

1 reference

24 April 2018

Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18581&geneProductId=UniProtKB:P18581

determination method

high-affinity L-ornithine transmembrane transporter activity

determination method

1 reference

24 April 2018

Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18581&geneProductId=UniProtKB:P18581

determination method

L-lysine transmembrane transporter activity

determination method

1 reference

24 April 2018

Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18581&geneProductId=UniProtKB:P18581

determination method

transmembrane transporter activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

L-ornithine transmembrane transporter activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

L-lysine transmembrane transporter activity

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

integral component of membrane

determination method

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

14 February 2019

Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

determination method

2 references

plasma membrane

determination method

3 references

determination method

2 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

biological process

nitric oxide biosynthetic process

determination method

1 reference

14 February 2019

CAT2 arginine transporter deficiency significantly reduces iNOS-mediated NO production in astrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

regulation of inflammatory response

determination method

1 reference

14 February 2019

Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

L-lysine import across plasma membrane

determination method

L-arginine import across plasma membrane

determination method

L-ornithine import across plasma membrane

determination method

1 reference

24 April 2018

Control of cationic amino acid transport and retroviral receptor functions in a membrane protein family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18581&geneProductId=UniProtKB:P18581

determination method

macrophage activation

determination method

1 reference

14 February 2019

Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

L-ornithine transmembrane transport

determination method

1 reference

24 April 2018

Identification of a low affinity, high capacity transporter of cationic amino acids in mouse liver

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18581&geneProductId=UniProtKB:P18581

determination method

amino acid transport

determination method

2 references

regulation of macrophage activation

determination method

1 reference

14 February 2019

Arginine transport via cationic amino acid transporter 2 plays a critical regulatory role in classical or alternative activation of macrophages

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

transmembrane transport

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

L-arginine import across plasma membrane

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

L-ornithine transmembrane transport

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

L-lysine transmembrane transport

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18581

determination method

Cationic amino acid transporter, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18581

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000113729

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000113729

ENSMUSP00000058866

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000058866

ENSMUSP00000112848

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000112848

ENSMUSP00000096414

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000096414

ENSMUSP00000114675

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000114675

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

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