Oligodendrocyte transcription factor 2 (Q21985470)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9EQW6

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9EQW6

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

1 reference

14 February 2019

protein dimerization activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

1 reference

14 February 2019

protein homodimerization activity

1 reference

14 February 2019

Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

DNA-binding transcription factor activity

Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

14 February 2019

14 February 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

HMG box domain binding

1 reference

14 February 2019

The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

protein binding

4 references

14 February 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

14 February 2019

Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

14 February 2019

An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

14 February 2019

Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

11 October 2018

Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQW6&geneProductId=UniProtKB:Q9EQW6

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

14 February 2019

Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

transcription regulator complex

cell component

ISS

1 reference

14 February 2019

Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

ISS

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

3 references

14 February 2019

14 February 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

14 February 2019

The progenitor zone of the ventral medial ganglionic eminence requires Nkx2-1 to generate most of the globus pallidus but few neocortical interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

positive regulation of oligodendrocyte differentiation

biological process

1 reference

14 February 2019

Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

regulation of transcription, DNA-templated

Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

14 February 2019

14 February 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

negative regulation of neuron differentiation

1 reference

14 February 2019

Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

thalamus development

1 reference

14 February 2019

Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

spinal cord oligodendrocyte cell fate specification

1 reference

14 February 2019

Ascl1 is required for oligodendrocyte development in the spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9EQW6&geneProductId=UniProtKB:Q9EQW6

1 reference

27 March 2018

nervous system development

1 reference

14 February 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

1 reference

14 February 2019

oligodendrocyte cell fate specification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

1 reference

14 February 2019

neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

1 reference

14 February 2019

neuron fate commitment

1 reference

14 February 2019

Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

spinal cord motor neuron differentiation

1 reference

14 February 2019

Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

spinal cord oligodendrocyte cell differentiation

1 reference

14 February 2019

Ascl1 is required for oligodendrocyte development in the spinal cord

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9EQW6

Myc-type, basic helix-loop-helix (bHLH) domain

has part(s)

1 reference

InterPro Release 71.0