Neurogenin 3 (Q21985883)

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mammalian protein found in Mus musculus

NGN-3
Neurog3
helix-loop-helix protein mATH-4B
mATH4B
neurogenin-3
atonal homolog 5
protein atonal homolog 5
Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B)

Language	Label	Description	Also known as
English	Neurogenin 3	mammalian protein found in Mus musculus	NGN-3 Neurog3 helix-loop-helix protein mATH-4B mATH4B neurogenin-3 atonal homolog 5 protein atonal homolog 5 Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B)

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Helix-loop-helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70661

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70661

Myc-type, basic helix-loop-helix (bHLH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

protein dimerization activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

DNA-binding transcription factor activity

determination method or standard

1 reference

14 February 2019

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

transcription coactivator activity

determination method or standard

1 reference

14 February 2019

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method or standard

4 references

5 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

protein binding

determination method or standard

1 reference

14 February 2019

Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

chromatin DNA binding

determination method or standard

1 reference

14 February 2019

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method or standard

4 references

5 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

5 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

DNA-binding transcription activator activity, RNA polymerase II-specific

determination method or standard

1 reference

7 November 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

intracellular anatomical structure

determination method or standard

2 references

5 June 2018

Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

5 June 2018

Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

determination method or standard

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

biological process

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

cell differentiation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

epithelial cell differentiation

determination method or standard

1 reference

14 February 2019

Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

positive regulation of DNA-binding transcription factor activity

determination method or standard

1 reference

14 February 2019

Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

hindbrain development

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

nervous system development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

regulation of dendrite morphogenesis

determination method or standard

1 reference

14 February 2019

Formin1 mediates the induction of dendritogenesis and synaptogenesis by neurogenin3 in mouse hippocampal neurons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

positive regulation of cell differentiation

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

spinal cord development

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

forebrain development

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

14 February 2019

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

transdifferentiation

determination method or standard

1 reference

14 February 2019

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70661

determination method or standard

transcription by RNA polymerase II

determination method or standard

1 reference

5 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P70661&geneProductId=UniProtKB:P70661

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

Myc-type, basic helix-loop-helix (bHLH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P70661

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000054054

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000054054

ENSMUSP00000151551

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000151551

Sitelinks

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Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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