Axin 1 (Q21981220)

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mammalian protein found in Mus musculus
  • axin-1
  • axis inhibition protein 1
  • protein Fused
  • Axin1
edit
Language Label Description Also known as
English
Axin 1
mammalian protein found in Mus musculus
  • axin-1
  • axis inhibition protein 1
  • protein Fused
  • Axin1

Statements

molecular function
protein binding
determination method or standard
IPI
26 references
retrieved
9 May 2019
stated in
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida
GOA
curator
UniProt
UniProt protein ID
O35625
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction of dishevelled and Xenopus axin-related protein is required for wnt signal transduction
GOA
curator
UniProt
UniProt protein ID
O35625
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification of zinc-finger BED domain-containing 3 (Zbed3) as a novel Axin-interacting protein that activates Wnt/beta-catenin signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification of a domain of Axin that binds to the serine/threonine protein phosphatase 2A and a self-binding domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Regulation of the Wnt signaling pathway by disabled-2 (Dab2)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Axin negatively affects tau phosphorylation by glycogen synthase kinase 3beta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
9 May 2019
stated in
Regulation of the Wnt signaling pathway by disabled-2 (Dab2)
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IPI
beta-catenin binding
determination method or standard
ISO
IMP
IPI
5 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
ISO
retrieved
24 April 2018
stated in
SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
24 April 2018
stated in
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
24 April 2018
stated in
Functional domains of axin. Importance of the C terminus as an oligomerization domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IPI
retrieved
24 April 2018
stated in
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IMP
cell component
plasma membrane
determination method or standard
IDA
IEA
ISO
NAS
6 references
retrieved
9 May 2019
stated in
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
NAS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
O35625
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IEA
retrieved
9 May 2019
stated in
The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
GOA
curator
UniProt
UniProt protein ID
O35625
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IDA
retrieved
9 May 2019
stated in
Frizzled-9 is activated by Wnt-2 and functions in Wnt/beta -catenin signaling
GOA
curator
UniProt
UniProt protein ID
O35625
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IDA
retrieved
9 May 2019
stated in
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35625
determination method or standard
IDA
biological process
negative regulation of Wnt signaling pathway
determination method or standard
IDA
ISO
5 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
ISO
retrieved
24 April 2018
stated in
A role for Wnt signalling in self-renewal of haematopoietic stem cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IDA
retrieved
24 April 2018
stated in
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IDA
retrieved
24 April 2018
stated in
A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IDA
retrieved
24 April 2018
stated in
A GSK3beta phosphorylation site in axin modulates interaction with beta-catenin and Tcf-mediated gene expression
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=O35625&geneProductId=UniProtKB:O35625
determination method or standard
IDA

Identifiers

 
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