Cadherin 2 (Q21981240)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15116

Cadherin-like superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15116

N-cadherin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P15116

membrane protein

1 reference

inferred from GOA cell component → membrane

Cadherin, cytoplasmic domain, protein family

1 reference

Cadherin prodomain, protein family

1 reference

Cadherin-like, protein family

1 reference

Cadherin conserved site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

1 reference

9 August 2016

11 references

9 August 2016

14 February 2019

Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPρ/PTPRT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

mARVCF cellular localisation and binding to cadherins is influenced by the cellular context but not by alternative splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Essential tyrosine residues for interaction of the non-receptor protein-tyrosine phosphatase PTP1B with N-cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

IPI

gamma-catenin binding

IEA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

3 references

alpha-catenin binding

3 references

3 references

14 February 2019

14 February 2019

Structure-function analysis of cell adhesion by neural (N-) cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

cytoskeletal protein binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

identical protein binding

3 references

14 February 2019

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

The extracellular architecture of adherens junctions revealed by crystal structures of type I cadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Two-step adhesive binding by classical cadherins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

protein homodimerization activity

IPI

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

nitric-oxide synthase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

6 references

9 August 2016

14 February 2019

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

integral component of membrane

IDA

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

2 references

9 August 2016

14 February 2019

Flotillin microdomains stabilize cadherins at cell-cell junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

1 reference

9 August 2016

4 references

9 August 2016

14 February 2019

Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

5 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Sex differences in expression and subcellular localization of heart rhythm determinant proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

POPX2 phosphatase regulates the KIF3 kinesin motor complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

1 reference

9 August 2016

1 reference

9 August 2016

cortical actin cytoskeleton

3 references

1 reference

9 August 2016

extracellular exosome

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

3 references

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

integral component of plasma membrane

1 reference

14 February 2019

Structure-function analysis of cell adhesion by neural (N-) cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

The kinase domains of obscurin interact with intercellular adhesion proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

3 references

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

3 references

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Role of β-Catenin in Synaptic Vesicle Localization and Presynaptic Assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

regulation of signal transduction

biological process

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

cell-cell adhesion mediated by cadherin

IEA

1 reference

9 August 2016

blood vessel morphogenesis

1 reference

9 August 2016

5 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Beating is necessary for transdifferentiation of skeletal muscle‐derived cells into cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

homophilic cell adhesion via plasma membrane adhesion molecules

IDA

1 reference

9 August 2016

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

1 reference

9 August 2016

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

cell-cell junction assembly

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

homophilic cell adhesion via plasma membrane adhesion molecules

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

N-Acetylglucosaminyltransferase V Expression Levels Regulate Cadherin-associated Homotypic Cell-Cell Adhesion and Intracellular Signaling Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

N-Acetylglucosaminyltransferase V Expression Levels Regulate Cadherin-associated Homotypic Cell-Cell Adhesion and Intracellular Signaling Pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

regulation of myelination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

regulation of protein localization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

adherens junction organization

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

regulation of Rho protein signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

modulation of chemical synaptic transmission

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

protein heterooligomerization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

protein localization to plasma membrane

1 reference

14 February 2019

Flotillin microdomains stabilize cadherins at cell-cell junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Structure-function analysis of cell adhesion by neural (N-) cadherin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P15116

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016