Sirtuin 5 (Q21983822)

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mammalian protein found in Mus musculus

SIR2-like protein 5
Regulatory protein SIR2 homolog 5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
NAD-dependent protein deacylase sirtuin-5, mitochondrial
NAD-dependent deacetylase sirtuin-5
Sirt5

Language	Label	Description	Also known as
English	Sirtuin 5	mammalian protein found in Mus musculus	SIR2-like protein 5 Regulatory protein SIR2 homolog 5 NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial NAD-dependent protein deacylase sirtuin-5, mitochondrial NAD-dependent deacetylase sirtuin-5 Sirt5

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Sirtuin, class III

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8K2C6

DHS-like NAD/FAD-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8K2C6

Sirtuin, catalytic core small domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8K2C6

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein-succinyllysine desuccinylase activity

determination method or standard

9 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

protein-malonyllysine demalonylase activity

determination method or standard

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

metal ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

hydrolase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

protein binding

determination method or standard

1 reference

14 February 2019

SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

zinc ion binding

determination method or standard

protein-glutaryllysine deglutarylase activity

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

determination method or standard

8 references

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

1 January 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

1 January 2018

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

1 January 2018

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

1 January 2018

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

1 January 2018

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

mitochondrial inner membrane

determination method or standard

1 reference

14 February 2019

Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

mitochondrial intermembrane space

determination method or standard

mitochondrial matrix

determination method or standard

determination method or standard

8 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

biological process

protein deacetylation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

regulation of ketone biosynthetic process

determination method or standard

1 reference

14 February 2019

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

peptidyl-lysine deglutarylation

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

negative regulation of cardiac muscle cell apoptotic process

determination method or standard

1 reference

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8K2C6&geneProductId=UniProtKB:Q8K2C6

determination method or standard

response to nutrient levels

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

protein demalonylation

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

peptidyl-lysine demalonylation

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

protein desuccinylation

determination method or standard

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

peptidyl-lysine desuccinylation

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

The first identification of lysine malonylation substrates and its regulatory enzyme

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

protein deglutarylation

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

14 February 2019

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8K2C6

determination method or standard

Sirtuin family, catalytic core domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8K2C6

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000071048

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000071048

ENSMUSP00000152526

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000152526

ENSMUSP00000152640

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000152640

ENSMUSP00000152668

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000152668

ENSMUSP00000152740

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000152740

ENSMUSP00000152760

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000152760

ENSMUSP00000152763

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000152763

ENSMUSP00000152796

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000152796

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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