Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction? (Q22251049)

Dimensions Publication ID

Dimensions

6 February 2023

Joyce E. Ohm

2

Joyce E.

Ohm

1 reference

Dimensions Publication ID

Dimensions

1041169608

Creation of human tumour cells with defined genetic elements

6 February 2023

language of work or name

English

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publication date

February 2006

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published in

Nature Reviews Cancer

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volume

6

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issue

2

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page(s)

107-116

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cites work

1 reference

31 March 2020

The Hallmarks of Cancer

1 reference

Clues to the pathogenesis of familial colorectal cancer

31 March 2020

1 reference

Lessons from hereditary colorectal cancer

31 March 2020

1 reference

Cancer-susceptibility genes. Gatekeepers and caretakers

31 March 2020

1 reference

Cancer epigenetics comes of age

31 March 2020

1 reference

The history of cancer epigenetics

31 March 2020

1 reference

Gene silencing in cancer in association with promoter hypermethylation

31 March 2020

1 reference

The fundamental role of epigenetic events in cancer

31 March 2020

1 reference

Global histone modification patterns predict risk of prostate cancer recurrence

31 March 2020

1 reference

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

31 March 2020

1 reference

Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

31 March 2020

1 reference

An epigenetic road map for histone lysine methylation

31 March 2020

1 reference

The language of covalent histone modifications

31 March 2020

1 reference

Histone and chromatin cross-talk

31 March 2020

1 reference

Linking the epigenetic 'language' of covalent histone modifications to cancer

31 March 2020

1 reference

Detection and interpretation of altered methylation patterns in cancer cells

31 March 2020

1 reference

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

31 March 2020

1 reference

Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

31 March 2020

1 reference

Methylation profiling of CpG islands in human breast cancer cells

31 March 2020

1 reference

PAX6 methylation and ectopic expression in human tumor cells

31 March 2020

1 reference

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer

31 March 2020

1 reference

Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma.

31 March 2020

1 reference

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

31 March 2020

1 reference

Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene.

31 March 2020

1 reference

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

31 March 2020

1 reference

GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer

31 March 2020

1 reference

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

31 March 2020

1 reference

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

31 March 2020

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Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation

31 March 2020

1 reference

Gastroprotective peptide trefoil factor family 2 gene is activated by upstream stimulating factor but not by c-Myc in gastrointestinal cancer cells.

31 March 2020

1 reference

The trefoil factor 1 participates in gastrointestinal cell differentiation by delaying G1-S phase transition and reducing apoptosis

31 March 2020

1 reference

Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer.

31 March 2020

1 reference

CpG island methylator phenotype in cancer

31 March 2020

1 reference

Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis

31 March 2020

1 reference

Loss of IGF2 imprinting: a potential marker of colorectal cancer risk

31 March 2020

1 reference

Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice

31 March 2020

1 reference

Global loss of imprinting leads to widespread tumorigenesis in adult mice

31 March 2020

1 reference

Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

31 March 2020

1 reference

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

31 March 2020

1 reference

Frequent aberrant methylation of p16INK4a in primary rat lung tumors

31 March 2020

1 reference

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis

31 March 2020

1 reference

Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes

31 March 2020

1 reference

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

31 March 2020

1 reference

31 March 2020

1 reference

Progressive region-specific de novo methylation of the p16 CpG island in primary human mammary epithelial cell strains during escape from M(0) growth arrest

31 March 2020

1 reference

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer

31 March 2020

1 reference

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

31 March 2020

1 reference

Cancer. Addiction to oncogenes--the Achilles heal of cancer

31 March 2020

1 reference

Wnt signaling in the intestinal epithelium: from endoderm to cancer

31 March 2020

1 reference

Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis

31 March 2020

1 reference

The induction of aberrant crypt foci (ACF) in the colons of rats by trihalomethanes administered in the drinking water

31 March 2020

1 reference

Aberrant crypt foci and beta-catenin accumulated crypts; significance and roles for colorectal carcinogenesis

31 March 2020

1 reference

Azoxymethane-induced colon tumors and aberrant crypt foci in mice of different genetic susceptibility

31 March 2020

1 reference

Sequential and morphological analyses of aberrant crypt foci formation in mice of differing susceptibility to azoxymethane-induced colon carcinogenesis

31 March 2020

1 reference

Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action

31 March 2020

1 reference

SARPs: a family of secreted apoptosis-related proteins

31 March 2020

1 reference

A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors

31 March 2020

1 reference

Shutting down Wnt signal-activated cancer

31 March 2020

1 reference

p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

31 March 2020

1 reference

Identification in the human candidate tumor suppressor gene HIC-1 of a new major alternative TATA-less promoter positively regulated by p53

31 March 2020

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Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

31 March 2020

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Mice deficient in the candidate tumor suppressor gene Hic1 exhibit developmental defects of structures affected in the Miller-Dieker syndrome.

31 March 2020

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Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors

31 March 2020

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Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis

31 March 2020

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

31 March 2020

1 reference

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

31 March 2020

1 reference

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

31 March 2020

1 reference

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

31 March 2020

1 reference

Negative control of p53 by Sir2alpha promotes cell survival under stress

31 March 2020

1 reference

Distinct epigenetic changes in the stromal cells of breast cancers

31 March 2020

1 reference

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

31 March 2020

1 reference

Stromal cells can contribute oncogenic signals

31 March 2020

1 reference

Epigenetics in human disease and prospects for epigenetic therapy

31 March 2020

1 reference

31 March 2020

1 reference

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

31 March 2020

1 reference

Translating the Histone Code

31 March 2020

1 reference

Histone methylation in transcriptional control

31 March 2020

1 reference

Polycomb complexes and silencing mechanisms.

31 March 2020

1 reference

Positions of potential: nuclear organization and gene expression.

31 March 2020

1 reference

Division of labor in polycomb group repression

31 March 2020

1 reference

Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins

31 March 2020

1 reference

Stem cells and cancer; the polycomb connection

31 March 2020

1 reference

Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

31 March 2020

1 reference

31 March 2020

Epigenetics and cancer

1 reference

The polycomb group protein EZH2 is involved in progression of prostate cancer

31 March 2020

1 reference

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

31 March 2020

1 reference

Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation

31 March 2020

1 reference

A portable signal causing faithful DNA methylation de novo in Neurospora crassa.

31 March 2020

1 reference

A histone H3 methyltransferase controls DNA methylation in Neurospora crassa

31 March 2020

1 reference

Synthesis of signals for de novo DNA methylation in Neurospora crassa

31 March 2020

1 reference

Physical mapping across the fragile X: hypermethylation and clinical expression of the fragile X syndrome

31 March 2020

1 reference

Control of CpNpG DNA methylation by the KRYPTONITE histone H3 methyltransferase

31 March 2020

1 reference

Interplay between two epigenetic marks. DNA methylation and histone H3 lysine 9 methylation

31 March 2020

1 reference

The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.

31 March 2020

1 reference

Role of histone H3 lysine 27 methylation in X inactivation

31 March 2020

1 reference

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

31 March 2020

1 reference

Heterochromatin: stable and unstable invasions at home and abroad

31 March 2020

1 reference

Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.

31 March 2020

1 reference

Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure

31 March 2020

1 reference

Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells

31 March 2020

1 reference

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

31 March 2020

1 reference

The power and the promise of DNA methylation markers

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC1799

1 reference

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1041169608

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Fatcat ID

release_bvy2ylqcdngydjbqodmpqla37i

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Fatcat

https://api.fatcat.wiki/v0/release/bvy2ylqcdngydjbqodmpqla37i

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

16491070

1 reference

Consolidated OpenCitations Corpus – April 2017