Identification of a cryptic nucleolar-localization signal in MDM2 (Q22253304)

GOA release 2020-03-11

M A Lohrum

1

Marion A. E.

Lohrum

1 reference

7 February 2023

M Ashcroft

series ordinal

2

author given names

Margaret

author last names

Ashcroft

1 reference

7 February 2023

M H Kubbutat

series ordinal

3

author given names

Michael H. G.

author last names

Kubbutat

1 reference

7 February 2023

K H Vousden

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4

author given names

Karen H.

author last names

Vousden

1 reference

Mechanisms of p53-mediated apoptosis

7 February 2023

language of work or name

English

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publication date

March 2000

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published in

Nature Cell Biology

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volume

2

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issue

3

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page(s)

179-81

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cites work

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7 January 2021

Keeping an old friend under control: regulation of p53 stability

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7 January 2021

Tumor surveillance via the ARF-p53 pathway.

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7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

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7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

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7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

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7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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7 January 2021

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

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7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

7 January 2021

Identifiers

DOI

10.1038/35004057

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