Alzheimer's disease is type 3 diabetes-evidence reviewed (Q34020000)

30 July 2017

1 reference

title

Alzheimer's disease is type 3 diabetes-evidence reviewed (English)

1 reference

30 July 2017

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Suzanne M de la Monte

series ordinal

1

1 reference

30 July 2017

Jack R Wands

series ordinal

2

1 reference

30 July 2017

publication date

1 November 2008

1 reference

Journal of Diabetes Science and Technology

30 July 2017

published in

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30 July 2017

volume

2

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30 July 2017

issue

6

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30 July 2017

page(s)

1101-1113

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Limited Alzheimer-type neurodegeneration in experimental obesity and type 2 diabetes mellitus.

30 July 2017

cites work

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The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease

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Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy

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5 July 2018

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Reduced brain antioxidant capacity in rat models of betacytotoxic-induced experimental sporadic Alzheimer's disease and diabetes mellitus

5 July 2018

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Defective IGF2 and IGF1R protein production in embryonic pancreas precedes beta cell mass anomaly in the Goto-Kakizaki rat model of type 2 diabetes

5 July 2018

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5 July 2018

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Update on non-alcoholic fatty liver disease in children

5 July 2018

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Therapeutic use of agonists of the nuclear receptor PPARgamma in Alzheimer's disease

5 July 2018

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Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment

5 July 2018

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Body mass index in midlife and risk of Alzheimer disease and vascular dementia

5 July 2018

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Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

5 July 2018

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5 July 2018

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1. Fatty liver and non-alcoholic steatohepatitis

5 July 2018

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Non-alcoholic fatty liver disease. From insulin resistance to mitochondrial dysfunction.

5 July 2018

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The effect of borderline diabetes on the risk of dementia and Alzheimer's disease

5 July 2018

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Insulin resistance syndrome and Alzheimer disease: pathophysiologic mechanisms and therapeutic implications

5 July 2018

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Diabetes mellitus and dementia.

5 July 2018

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Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer's disease

5 July 2018

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Therapy Insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease

5 July 2018

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Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain.

5 July 2018

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Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease.

5 July 2018

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PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease

5 July 2018

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Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signalling pathway

5 July 2018

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Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

5 July 2018

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Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

5 July 2018

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5 July 2018

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The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease

5 July 2018

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

5 July 2018

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Review of insulin and insulin-like growth factor expression, signaling, and malfunction in the central nervous system: relevance to Alzheimer's disease.

5 July 2018

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Diabetes and brain aging: epidemiologic evidence

5 July 2018

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The role of inflammation in Alzheimer's disease

5 July 2018

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Intranasal insulin improves memory in humans

5 July 2018

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How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes

5 July 2018

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Cardiovascular risk factors and Alzheimer's disease

5 July 2018

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Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

5 July 2018

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

5 July 2018

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Can dementia be prevented? Brain aging in a population-based context

5 July 2018

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Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity

5 July 2018

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Neuroinflammatory perspectives on the two faces of Alzheimer's disease

5 July 2018

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Role for neuronal insulin resistance in neurodegenerative diseases

5 July 2018

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Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications.

5 July 2018

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The calpains in aging and aging-related diseases

5 July 2018

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Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation

5 July 2018

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Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase

5 July 2018

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5 July 2018

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Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

5 July 2018

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Death and survival of neuronal cells exposed to Alzheimer's insults

5 July 2018

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Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease.

5 July 2018

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Diabetic neuropathies in brain are induced by deficiency of BDNF.

5 July 2018

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The brain insulin signal transduction system and sporadic (type II) Alzheimer disease: an update

5 July 2018

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The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas

5 July 2018

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Impaired brain development and hydrocephalus in a line of transgenic mice with liver-specific expression of human insulin-like growth factor binding protein-1.

5 July 2018

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Partial rescue of ethanol-induced neuronal apoptosis by growth factor activation of phosphoinositol-3-kinase

5 July 2018

1 reference

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Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats

5 July 2018

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Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

5 July 2018

1 reference

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Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats

5 July 2018

1 reference

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Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

5 July 2018

1 reference

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Assessment of the pathological stages of Alzheimer's disease in thin paraffin sections: a comparative study

5 July 2018

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Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

5 July 2018

1 reference

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Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons

5 July 2018

1 reference

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Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

5 July 2018

1 reference

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

5 July 2018

1 reference

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Amyloid fibril toxicity in Alzheimer's disease and diabetes

5 July 2018

1 reference

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Role of forebrain cholinergic systems in learning and memory: relevance to the cognitive deficits of aging and Alzheimer's dementia

5 July 2018

1 reference

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Synaptic pathology of Alzheimer's disease

5 July 2018

1 reference

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Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus

5 July 2018

1 reference

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The IRS-1 signaling system

5 July 2018

1 reference

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Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism.

5 July 2018

1 reference

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Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

5 July 2018

1 reference

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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Insulin-Mediated Regulation of Neuronal Maturation

5 July 2018

1 reference

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Insulin, insulin-like growth factor II, and nerve growth factor effects on tubulin mRNA levels and neurite formation

5 July 2018

1 reference

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New perspectives on Alzheimer's disease

5 July 2018

1 reference

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

5 July 2018

1 reference

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Quantitation of cerebral atrophy in preclinical and end-stage Alzheimer's disease.

5 July 2018

1 reference

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Development of oligodendrocytes. Studies of rat glial cells cultured in chemically-defined medium.

5 July 2018

1 reference

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Intrinsic kinase activity of the insulin receptor.

5 July 2018

1 reference

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

5 July 2018

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Glycolytic enzymes from human autoptic brain cortex: Normal aged and demented cases

21 January 2018

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21 January 2018

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Insulin dose-response effects on memory and plasma amyloid precursor protein in Alzheimer's disease: interactions with apolipoprotein E genotype

21 January 2018

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Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype.

21 January 2018

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Insulin resistance and cognitive impairment: a view through the prism of epidemiology.

21 January 2018

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Ethanol impairs insulin-stimulated mitochondrial function in cerebellar granule neurons

21 January 2018

1 reference

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Chronic gestational exposure to ethanol impairs insulin-stimulated survival and mitochondrial function in cerebellar neurons

21 January 2018

1 reference

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Memory impairment in obese Zucker rats: an investigation of cognitive function in an animal model of insulin resistance and obesity.

21 January 2018

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Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761).

21 January 2018

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Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Insulin effects on CSF norepinephrine and cognition in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Relation of diabetes to mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Brain aging in very old men with type 2 diabetes: the Honolulu-Asia Aging Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Increased risk of type 2 diabetes in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Lower levels of circulating IGF-I in Type 1 diabetic women with frequent severe hypoglycaemia during pregnancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Diagnostic criteria for neuropathologic assessment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Neuronal thread protein regulation and interaction with microtubule-associated proteins in SH-Sy5y neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Characterization of the toxic mechanism triggered by Alzheimer's amyloid-beta peptides via p75 neurotrophin receptor in neuronal hybrid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Intracerebroventricular injection of streptozotocin induces discrete local changes in cerebral glucose utilization in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Synapse Loss and Gliosis in the Molecular Layer of the Cerebral Cortex in Alzheimer's Disease and in Frontal Lobe Degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Expression of the gene encoding the tyrosine kinase-deficient human insulin receptor in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

The neurobiology and pharmacotherapy of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Intranasal insulin improves memory in humans: superiority of insulin aspart

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer's disease.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Risk factors for cognitive impairment

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

[Non-alcoholic steatohepatitis].

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Oxidative alterations in Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Brain glutamate dehydrogenase changes in streptozotocin diabetic rats as a function of age.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Bax protein expression is increased in Alzheimer's brain: correlations with DNA damage, Bcl-2 expression, and brain pathology

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2769828

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

29 October 2018

1 reference

https://api.crossref.org/works/10.1177%2F193229680800200619

Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19885299

12 December 2020

inferred from PubMed ID database lookup

Does IGF-I stimulate pancreatic islet cell growth?

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19885299

12 December 2020

inferred from PubMed ID database lookup

The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19885299

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1177/193229680800200619

1 reference

release_cdyibmdi2vfsrjc3s4pf2emvpq

30 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/cdyibmdi2vfsrjc3s4pf2emvpq

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2769828

1 reference

30 July 2017

1 reference