Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. (Q34049911)

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English	Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels.	scientific article

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12 January 2020

Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels (English)

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12 January 2020

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Timothy G. Buchman

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12 January 2020

Richard S Hotchkiss

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Richard S Hotchkiss

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12 January 2020

Craig M Coopersmith

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Craig M Coopersmith

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12 January 2020

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Dinesh Vyas

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12 January 2020

Pardis Javadi

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12 January 2020

Peter J Dipasco

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12 January 2020

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9 June 2005

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12 January 2020

American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

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12 January 2020

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12 January 2020

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12 January 2020

R1048-53

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12 January 2020

Role of interleukin-6 in mortality from and physiologic response to sepsis

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28 July 2018

Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels

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28 July 2018

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28 July 2018

Circulating inflammatory mediators predict shock and mortality in febrile patients with microbial infection

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28 July 2018

The Surgical Infection Society guidelines on antimicrobial therapy for intra-abdominal infections: an executive summary

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28 July 2018

Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia

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28 July 2018

Early goal-directed therapy in the treatment of severe sepsis and septic shock

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28 July 2018

Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care

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28 July 2018

Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients

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28 July 2018

Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat.

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28 July 2018

Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE) III scores and survival in patients in an intensive care unit

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28 July 2018

Interleukin-6 is required for a protective immune response to systemic Escherichia coli infection

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28 July 2018

Increased plasma levels of interleukin-6 in sepsis

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28 July 2018

Efficacy and safety of recombinant human activated protein C for severe sepsis

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21 January 2018

Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia

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21 January 2018

Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi.

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21 January 2018

Six at six: interleukin-6 measured 6 h after the initiation of sepsis predicts mortality over 3 days

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21 January 2018

Genetic contribution to the septic response in a mouse model

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21 January 2018

Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels

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21 January 2018

Extremely high interleukin-6 blood levels and outcome in the critically ill are associated with tumor necrosis factor- and interleukin-1-related gene polymorphisms.

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21 January 2018

Correction of perioperative hypothermia decreases experimental sepsis mortality by modulating the inflammatory response

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21 January 2018

Antibiotic treatment in a murine model of sepsis: impact on cytokines and endotoxin release

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28 October 2018

Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice.

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28 October 2018

Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model.

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28 October 2018

AGE DISPROPORTIONATELY INCREASES SEPSIS-INDUCED APOPTOSIS IN THE SPLEEN AND GUT EPITHELIUM

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21 January 2018

Relationship between interleukin-6 plasma concentration in patients with sepsis, monocyte phenotype, monocyte phagocytic properties, and cytokine production

1 reference

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12 December 2020

based on heuristic

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Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15947070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-interleukin-6 antibody treatment improves survival during gut-derived sepsis in a time-dependent manner by enhancing host defense

1 reference

https://pubmed.ncbi.nlm.nih.gov/15947070

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitivity and specificity of various markers of inflammation for the prediction of tumor necrosis factor-alpha and interleukin-6 in patients with sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15947070

12 December 2020

based on heuristic

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10.1152/AJPREGU.00312.2005

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Europe PubMed Central

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12 January 2020

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24 November 2022

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12 January 2020

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12 January 2020

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