The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review (Q34062707)

30 July 2017

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title

The role of NAD(P)H oxidoreductase (DT-Diaphorase) in the bioactivation of quinone-containing antitumor agents: a review (English)

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30 July 2017

Gutierrez PL

1

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30 July 2017

publication date

1 August 2000

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Free Radical Biology and Medicine

30 July 2017

published in

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30 July 2017

volume

29

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30 July 2017

issue

3-4

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30 July 2017

page(s)

263-275

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One-electron-transfer reactions in biochemical systems. 3. One-electron reduction of quinones by microsomal flavin enzymes

30 July 2017

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7 January 2021

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Over-expression of glutathione S-transferases, DT-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of the human parotid gland

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7 January 2021

DT-diaphorase and cytochrome B5 reductase in human lung and breast tumours

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DT-diaphorase and cancer chemotherapy

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DT-diaphorase in activation and detoxification of quinones. Bioreductive activation of mitomycin C.

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7 January 2021

Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity

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7 January 2021

The electrophile counterattack response: protection against neoplasia and toxicity.

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7 January 2021

Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents

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7 January 2021

DT-diaphorase as a quinone reductase: a cellular control device against semiquinone and superoxide radical formation

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7 January 2021

Formation of benzo[a]pyrene-3,6-quinol mono- and diglucuronides in rat liver microsomes.

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7 January 2021

Autoxidation of naphthohydroquinones: effects of metals, chelating agents, and superoxide dismutase

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7 January 2021

Inhibition of naphthohydroquinone autoxidation by DT-diaphorase (NAD(P)H:[quinone acceptor] oxidoreductase)

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7 January 2021

Mechanism for the reductive activation of diaziquone.

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7 January 2021

Adriamycin and DT-diaphorase

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7 January 2021

Enzyme induction by daunorubicin in neonatal heart cells in culture

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7 January 2021

A comparison of free radical formation by quinone antitumour agents in MCF-7 cells and the role of NAD(P)H (quinone-acceptor) oxidoreductase (DT-diaphorase)

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7 January 2021

Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase

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7 January 2021

Dinitropyrene nitroreductase activity of purified NAD(P)H-quinone oxidoreductase: role in rat liver cytosol and induction by Aroclor-1254 pretreatment.

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7 January 2021

Nitrobenzimidazoles as substrates for DT-diaphorase and redox cycling compounds: their enzymatic reactions and cytotoxicity.

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7 January 2021

The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Tumour-growth inhibitory nitrophenylaziridines and related compounds: Structure-activity relationships. II

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7 January 2021

CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells

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7 January 2021

A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

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7 January 2021

Tumour-growth inhibitorynitrofphenylaziridines and related compounds structure-activity relationships

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7 January 2021

2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256.

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7 January 2021

The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)

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7 January 2021

The changes of prooxidant and antioxidant enzyme activities in bovine leukemia virus-transformed cells. Their influence on quinone cytotoxicity

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7 January 2021

The toxicity of aromatic nitrocompounds to bovine leukemia virus-transformed fibroblasts: the role of single-electron reduction

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7 January 2021

Quantitative structure activity relationships for the conversion of nitrobenzimidazolones and nitrobenzimidazoles by DT-diaphorase: implications for the kinetic mechanism

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7 January 2021

Mechanism(s) for the metabolism of mitoxantrone: electron spin resonance and electrochemical studies.

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7 January 2021

NAD(P)H (quinone acceptor) oxidoreductase (DT-diaphorase)-mediated two-electron reduction of anthraquinone-based antitumour agents and generation of hydroxyl radicals

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7 January 2021

Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer

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7 January 2021

Comparative computer graphics and solution studies of the DNA interaction of substituted anthraquinones based on doxorubicin and mitoxantrone

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7 January 2021

Redox cycling in MCF-7 human breast cancer cells by antitumor agents based on mitozantrone

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Involvement of hydroxyl radical formation and DNA strand breakage in the cytotoxicity of anthraquinone antitumour agents

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Anticancer quinones induce pRb-preventable G2/M cell cycle arrest and apoptosis

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Mitomycin C: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Re-evaluation of the molecular pharmacology of mitomycin C.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Bioreductive drugs as post-irradiation sensitizers: comparison of dual function agents with SR 4233 and the mitomycin C analogue EO9

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Non-enzymatic and enzymatic activation of mitomycin C: identification of a unique cytosolic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Bioreductive activation of mitomycin C by DT-diaphorase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Increased sensitivity of quinone resistant cells to mitomycin C.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

The autoxidation of the reduced forms of EO9

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7 January 2021

Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia

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7 January 2021

Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Pharmacological and biochemical determinants of the antitumour activity of the indoloquinone EO9

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7 January 2021

A randomized phase II study with two schedules of the novel indoloquinone EO9 in non-small-cell lung cancer: a study of the EORTC Early Clinical Studies Group (ECSG)

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7 January 2021

Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Generation of semiquinone radical from carbazilquinone by NADPH-cytochrome P-450 reductase

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7 January 2021

Potential central nervous system antitumor agents. Aziridinylbenzoquinones. 1

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7 January 2021

Aziridinylbenzoquinone in recurrent, progressive glioma of the central nervous system. A Phase II study by the Illinois Cancer Council

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Mechanism(s) of bioreductive activation. The example of diaziquone (AZQ).

1 reference

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7 January 2021

Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

The reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells: free radical formation and NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase) activity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Reductive metabolism of diaziquone (AZQ) in the S9 fraction of MCF-7 cells. II. Enhancement of the alkylating activity of AZQ by NAD(P)H: quinone-acceptor oxidoreductase (DT-diaphorase)

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Free radical formation and DNA strand breakage during metabolism of diaziquone by NAD(P)H quinone-acceptor oxidoreductase (DT-diaphorase) and NADPH cytochrome c reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Extracellular activation of fluorinated aziridinylbenzoquinone in HT29 cells EPR studies.

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7 January 2021

Reactions of halogen-substituted aziridinylbenzoquinones with glutathione. Formation of diglutathionyl conjugates and semiquinones

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7 January 2021

Enzymic- and thiol-mediated activation of halogen-substituted diaziridinylbenzoquinones: redox transitions of the semiquinone and semiquinone-thioether species

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7 January 2021

Molecular mechanisms of trenimon-induced cytotoxicity in resistant L5178Y/HBM10 cells

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Disruption of the DT diaphorase (NQO1) gene in mice leads to increased menadione toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Effects of butylated hydroxyanisole and dicoumarol on the toxicity of menadione to rats

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7 January 2021

Enzymatic and molecular aspects of the antioxidant effect of menadione in hepatic microsomes

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

Quinone toxicity in DT-diaphorase-efficient and -deficient colon carcinoma cell lines

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https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900314-2

7 January 2021

The influence of ascorbic acid on the free-radical metabolism of xenobiotics: the example of diaziquone

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7 January 2021

Induction of p53 by the concerted actions of aziridine and quinone moieties of diaziquone

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7 January 2021

The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells

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7 January 2021

Induction of p21 mediated by reactive oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells

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7 January 2021

10.1016/S0891-5849(00)00314-2

Identifiers

DOI

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30 July 2017

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