In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB) (Q34073529)

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English	In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB)	scientific article

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30 January 2020

In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB) (English)

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30 January 2020

Mariangela Figini

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30 January 2020

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30 January 2020

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Carl H June

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30 January 2020

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De-Gang Song

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30 January 2020

Qunrui Ye

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30 January 2020

Carmine Carpenito

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30 January 2020

Mathilde Poussin

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30 January 2020

Li-Ping Wang

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30 January 2020

Chunyan Ji

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30 January 2020

Daniel J Powell

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30 January 2020

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5 May 2011

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30 January 2020

Cancer Research

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30 January 2020

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30 January 2020

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30 January 2020

4617-4627

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30 January 2020

Immune responses to transgene and retroviral vector in patients treated with ex vivo–engineered T cells

1 reference

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28 July 2018

Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.

1 reference

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28 July 2018

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

1 reference

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28 July 2018

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

1 reference

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28 July 2018

Conversion of murine antibodies to human antibodies and their optimization for ovarian cancer therapy targeted to the folate receptor.

1 reference

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Adoptive immunotherapy for indolent non-Hodgkin lymphoma and mantle cell lymphoma using genetically modified autologous CD20-specific T cells

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Single and dual amino acid substitutions in TCR CDRs can enhance antigen-specific T cell functions

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Folate receptor alpha as a tumor target in epithelial ovarian cancer

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Engineering artificial antigen-presenting cells to express a diverse array of co-stimulatory molecules.

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A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

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28 July 2018

Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes

1 reference

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Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy

1 reference

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A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

1 reference

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28 July 2018

Vaccine-stimulated, adoptively transferred CD8+ T cells traffic indiscriminately and ubiquitously while mediating specific tumor destruction.

1 reference

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28 July 2018

Cutting edge: persistence of transferred lymphocyte clonotypes correlates with cancer regression in patients receiving cell transfer therapy

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28 July 2018

Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

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28 July 2018

Molecular cloning of agonistic and antagonistic monoclonal antibodies against human 4-1BB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes

1 reference

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28 July 2018

Nonmyeloablative immunosuppressive regimen prolongs In vivo persistence of gene-modified autologous T cells in a nonhuman primate model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

Distant metastases in ovarian cancer: association with p53 mutations.

1 reference

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28 July 2018

Targeting of interleukin 2 to human ovarian carcinoma by fusion with a single-chain Fv of antifolate receptor antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

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Panning phage antibody libraries on cells: isolation of human Fab fragments against ovarian carcinoma using guided selection.

1 reference

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28 July 2018

4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

Overexpression of folate binding protein in ovarian cancers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

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Regression of Advanced Ovarian Carcinoma by Intraperitoneal Treatment With Autologous TLymphocytes Retargeted by a Bispecific Monoclonal Antibody

1 reference

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28 July 2018

Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

Anti-ovarian carcinoma anti-T3 heteroconjugates or hybrid antibodies induce tumor cell lysis by cytotoxic T-cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity

1 reference

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28 July 2018

Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

Folate-binding protein is a marker for ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4140173

28 July 2018

Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues

1 reference

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1 reference

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Expression of the folate receptor genes FOLR1 and FOLR3 differentiates ovarian carcinoma from breast carcinoma and malignant mesothelioma in serous effusions.

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Infiltration of tumors by systemically transferred tumor-reactive T lymphocytes is required for antitumor efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/21546571

12 December 2020

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Cutting edge: 4-1BB is a bona fide CD8 T cell survival signal

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https://pubmed.ncbi.nlm.nih.gov/21546571

12 December 2020

based on heuristic

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Adoptive transfer of chimeric antigen receptor re-directed cytolytic T lymphocyte clones in patients with neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21546571

12 December 2020

based on heuristic

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Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/21546571

12 December 2020

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10.1158/0008-5472.CAN-11-0422

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30 January 2020

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30 January 2020

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30 January 2020

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