BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly (Q34085175)

30 July 2017

title

BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly (English)

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30 July 2017

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Shiaw-Yih Lin

1

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30 July 2017

Rekha Rai

2

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30 July 2017

Kaiyi Li

3

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30 July 2017

Zhi-Xiang Xu

4

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30 July 2017

Stephen J Elledge

5

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30 July 2017

language of work or name

English

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publication date

10 October 2005

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Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

number of pages

5

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based on heuristic

inferred from page(s)

published in

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30 July 2017

volume

102

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30 July 2017

issue

42

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30 July 2017

page(s)

15105-15109

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Nbs1 is required for ATR-dependent phosphorylation events

30 July 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway.

5 July 2018

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Chk1 is haploinsufficient for multiple functions critical to tumor suppression

5 July 2018

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Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

5 July 2018

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

5 July 2018

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DNA damage checkpoint and repair centers

5 July 2018

1 reference

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DNA damage tumor suppressor genes and genomic instability

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

BRCA1 Inhibition of Telomerase Activity in Cultured Cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Multiple tumor suppressor pathways negatively regulate telomerase

5 July 2018

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A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome

5 July 2018

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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

5 July 2018

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Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks

5 July 2018

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Checking on the fork: the DNA-replication stress-response pathway

5 July 2018

1 reference

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53BP1, a mediator of the DNA damage checkpoint

5 July 2018

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Identification of microcephalin, a protein implicated in determining the size of the human brain

5 July 2018

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Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

5 July 2018

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

5 July 2018

1 reference

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ATM and ATR: networking cellular responses to DNA damage

5 July 2018

1 reference

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5 July 2018

BRCA1 and cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

The DNA damage response: putting checkpoints in perspective

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Megabase chromatin domains involved in DNA double-strand breaks in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

Radiosensitivity in ataxia-telangiectasia: a new explanation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1257745

DNA damage-induced cell-cycle phase regulation of p53 and p21waf1 in normal and ATM-defective cells

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0507722102

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0507722102

21 January 2018

Identifiers

DOI

10.1073/PNAS.0507722102

1 reference

30 July 2017

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30 July 2017

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