2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase (Q34116798)

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English	2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

31 July 2017

2-Phenyl-5-(pyrrolidin-1-yl)-1-(3,4,5-trimethoxybenzyl)-1H-benzimidazole, a benzimidazole derivative, inhibits growth of human prostate cancer cells by affecting tubulin and c-Jun N-terminal kinase (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

author name string

Wei-Ling Chang

1

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Europe PubMed Central

PubMed publication ID

31 July 2017

Chih-Shiang Chang

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

Po-Cheng Chiang

3

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Europe PubMed Central

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31 July 2017

Yunn-Fang Ho

4

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Europe PubMed Central

PubMed publication ID

31 July 2017

Ju-Fang Liu

5

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31 July 2017

Kai-Wei Chang

6

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31 July 2017

Jih-Hwa Guh

7

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31 July 2017

language of work or name

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publication date

1 August 2010

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Europe PubMed Central

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31 July 2017

British Journal of Pharmacology

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Europe PubMed Central

PubMed publication ID

31 July 2017

160

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Europe PubMed Central

PubMed publication ID

31 July 2017

7

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

1677-1689

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Induction of G2/M arrest, endoreduplication, and apoptosis by actin depolymerization agent pextenotoxin-2 in human leukemia cells, involving activation of ERK and JNK.

1 reference

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5 July 2018

To cell cycle, swing the APC/C.

1 reference

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5 July 2018

Distinct signaling pathways of microtubule inhibitors--vinblastine and Taxol induce JNK-dependent cell death but through AP-1-dependent and AP-1-independent mechanisms, respectively.

1 reference

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5 July 2018

Regulation of Bcl-2 family proteins by posttranslational modifications.

1 reference

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5 July 2018

The contribution of c-Jun N-terminal kinase activation and subsequent Bcl-2 phosphorylation to apoptosis induction in human B-cells is dependent on the mode of action of specific stresses

1 reference

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4'-methoxy-2-styrylchromone a novel microtubule-stabilizing antimitotic agent.

1 reference

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5 July 2018

The functional contrariety of JNK

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STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.

1 reference

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Combretastatin CA-4 and combretastatin derivative induce mitotic catastrophe dependent on spindle checkpoint and caspase-3 activation in non-small cell lung cancer cells.

1 reference

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1 reference

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Thymosinalpha1 stimulates cell proliferation by activating ERK1/2, JNK, and increasing cytokine secretion in human pancreatic cancer cells

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JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length

1 reference

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Albendazole for lymphatic filariasis

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JNK antagonizes Akt-mediated survival signals by phosphorylating 14-3-3.

1 reference

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Induction of p53 and drug resistance following treatment with cisplatin or paclitaxel in ovarian cancer cell lines

1 reference

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5 July 2018

Review: tubulin function, action of antitubulin drugs, and new drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

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CEP-11004, an inhibitor of the SAPK/JNK pathway, reduces TNF-alpha release from lipopolysaccharide-treated cells and mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

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BCR/ABL activates Rap1 and B-Raf to stimulate the MEK/Erk signaling pathway in hematopoietic cells.

1 reference

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Physiological roles of SAPK/JNK signaling pathway

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

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Microtubule-targeted anticancer agents and apoptosis

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

5 July 2018

The JNK signal transduction pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

5 July 2018

Caspase cleavage enhances the apoptosis-inducing effects of BAD.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

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Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

5 July 2018

Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2936840

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Identification of a novel inhibitor of mitogen-activated protein kinase kinase

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Antiproliferative effect in human prostatic smooth muscle cells by nitric oxide donor

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1 reference

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Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death

1 reference

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Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1 reference

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Polarized transport of docetaxel and vinblastine mediated by P-glycoprotein in human intestinal epithelial cell monolayers

1 reference

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Inactivation of Bcl-2 by phosphorylation

1 reference

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AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils

1 reference

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The JNK-dependent CaMK pathway restrains the reversion of committed cells during osteoclast differentiation

1 reference

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MEK1/2 is a critical regulator of microtubule assembly and spindle organization during rat oocyte meiotic maturation

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21 January 2018

Structure—Function Analysis of Bcl-2 Family Proteins

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https://pubmed.ncbi.nlm.nih.gov/20649571

12 December 2020

based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/20649571

12 December 2020

based on heuristic

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Identifiers

10.1111/J.1476-5381.2010.00832.X

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Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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