Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice (Q34132179)

31 July 2017

title

Glucagon deficiency reduces hepatic glucose production and improves glucose tolerance in adult mice (English)

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31 July 2017

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Aidan S Hancock

1

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31 July 2017

Aiping Du

2

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31 July 2017

Jingxuan Liu

3

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31 July 2017

Mayumi Miller

4

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31 July 2017

Catherine L May

5

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31 July 2017

publication date

30 June 2010

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31 July 2017

published in

Molecular Endocrinology

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31 July 2017

volume

24

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31 July 2017

issue

8

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31 July 2017

page(s)

1605-1614

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Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity

31 July 2017

cites work

1 reference

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Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells

5 July 2018

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Effects of insulin on the metabolic control of hepatic gluconeogenesis in vivo.

5 July 2018

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The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

5 July 2018

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CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis

5 July 2018

1 reference

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Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein

5 July 2018

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Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females

5 July 2018

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5 July 2018

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Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

5 July 2018

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Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver

5 July 2018

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The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas

5 July 2018

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Hepatic and glucagon-like peptide-1-mediated reversal of diabetes by glucagon receptor antisense oligonucleotide inhibitors

5 July 2018

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Opposing actions of Arx and Pax4 in endocrine pancreas development

5 July 2018

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5 July 2018

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Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

5 July 2018

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Mutation of ARX causes abnormal development of forebrain and testes in mice and X-linked lissencephaly with abnormal genitalia in humans

5 July 2018

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The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal cleavage site

5 July 2018

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Molecular and cellular aspects of the glucagon receptor: role in diabetes and metabolism.

5 July 2018

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Role of glucagon in maintenance of euglycemia in fed and fasted rats.

5 July 2018

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Glucagon and the Insulin:Glucagon Ratio in Diabetes and Other Catabolic Illnesses

5 July 2018

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Somatostatin: Hypothalamic Inhibitor of the Endocrine Pancreas

5 July 2018

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Role of liver in pathophysiology of NIDDM

5 July 2018

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Evidence for an important role of glucagon in the regulation of hepatic glucose production in normal man.

5 July 2018

1 reference

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Effect of glucagon on glucose production during insulin deficiency in the dog

5 July 2018

1 reference

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The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glucagon receptor signaling is essential for control of murine hepatocyte survival

28 October 2018

1 reference

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Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Autoregulation of endogenous glucose production during hyperglucagonemia

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glycemic control in mice with targeted disruption of the glucagon receptor gene

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Physiological changes in circulating glucagon alter hepatic glucose disposition during portal glucose delivery.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2940466

Glucagon: Role in the Hyperglycemia of Diabetes Mellitus

28 October 2018

1 reference

12 December 2020

Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon

1 reference

12 December 2020

Hyperglucagonemia and its suppression. Importance in the metabolic control of diabetes

1 reference

12 December 2020

Possible mechanism by which somatostatin-induced glucagon suppression improves glucose tolerance during insulinopaenia in man

1 reference

12 December 2020

The role of poly(ADP-ribose) synthetase in the development of insulin-dependent diabetes and islet B-cell regeneration

1 reference

12 December 2020

Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycaemia in moderately streptozotocin-diabetic rats

1 reference

12 December 2020

Evidence for a Major Role for Glucagon in Regulation of Plasma Glucose in Conscious, Nondiabetic, and Alloxan-Induced Diabetic Rabbits

1 reference

12 December 2020

Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function

1 reference

12 December 2020

Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia

1 reference

12 December 2020

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

1 reference

12 December 2020

Lack of suppression of glucagon contributes to postprandial hyperglycemia in subjects with type 2 diabetes mellitus

1 reference

12 December 2020

Identifiers

DOI

10.1210/ME.2010-0120

1 reference

31 July 2017

1 reference

31 July 2017

1 reference