Protein kinase B (PKB/Akt)--a key regulator of glucose transport? (Q34189344)

31 July 2017

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title

Protein kinase B (PKB/Akt)--a key regulator of glucose transport? (English)

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31 July 2017

Hajduch E

1

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31 July 2017

Litherland GJ

series ordinal

2

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31 July 2017

Hundal HS

series ordinal

3

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31 July 2017

language of work or name

English

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publication date

1 March 2001

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31 July 2017

number of pages

5

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based on heuristic

inferred from page(s)

published in

FEBS Letters

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31 July 2017

volume

492

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31 July 2017

issue

3

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31 July 2017

page(s)

199-203

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Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

31 July 2017

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Cellular survival: a play in three Akts

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From receptor to transporter: insulin signalling to glucose transport.

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The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

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Protein kinase B stimulates the translocation of GLUT4 but not GLUT1 or transferrin receptors in 3T3-L1 adipocytes by a pathway involving SNAP-23, synaptobrevin-2, and/or cellubrevin

7 January 2021

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Insulin increases the association of Akt-2 with Glut4-containing vesicles

7 January 2021

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Akt-2 binds to Glut4-containing vesicles and phosphorylates their component proteins in response to insulin

7 January 2021

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Rab11 is associated with GLUT4-containing vesicles and redistributes in response to insulin.

7 January 2021

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Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

7 January 2021

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Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

7 January 2021

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Evidence for involvement of protein kinase C (PKC)-zeta and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes

7 January 2021

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Protein kinase Czeta is a negative regulator of protein kinase B activity

7 January 2021

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Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes

7 January 2021

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An SH2 domain-containing 5' inositolphosphatase inhibits insulin-induced GLUT4 translocation and growth factor-induced actin filament rearrangement

7 January 2021

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The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

7 January 2021

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Tumour necrosis factor, a key role in obesity?

7 January 2021

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Signal transduction of stress via ceramide

7 January 2021

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Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress

7 January 2021

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Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

7 January 2021

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Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

7 January 2021

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Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes

7 January 2021

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7 January 2021

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Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

7 January 2021

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Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

7 January 2021

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7 January 2021

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Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress. Evidence for cross-talk between the insulin and SAPK2/p38 mitogen-activated protein kinase signaling pathways

7 January 2021

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Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation

7 January 2021

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Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes

7 January 2021

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Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state

7 January 2021

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Phosphatidylinositol 3-kinase and the actin network are not required for the stimulation of glucose transport caused by mitochondrial uncoupling: comparison with insulin action

7 January 2021

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Insulin resistance in fat cells from obese Zucker rats--evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4.

7 January 2021

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Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

7 January 2021

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Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats.

7 January 2021

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Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

7 January 2021

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Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle.

7 January 2021

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Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats

7 January 2021

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Thiazolidinedione treatment enhances insulin effects on protein kinase C-zeta /lambda activation and glucose transport in adipocytes of nondiabetic and Goto-Kakizaki type II diabetic rats

7 January 2021

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Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats

7 January 2021

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Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

7 January 2021

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Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search f

7 January 2021

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Effect of phosphoinositide-dependent kinase 1 on protein kinase B translocation and its subsequent activation

7 January 2021

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Regulation of protein kinase B and glycogen synthase kinase-3 by insulin and beta-adrenergic agonists in rat epididymal fat cells. Activation of protein kinase B by wortmannin-sensitive and -insensitive mechanisms

7 January 2021

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10.1016/S0014-5793(01)02242-6

7 January 2021

Identifiers

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31 July 2017

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