Drug discovery with engineered zinc-finger proteins (Q34197502)

31 July 2017

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title

Drug discovery with engineered zinc-finger proteins (English)

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31 July 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12750739

3 January 2024

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3 January 2024

author name string

Andrew C. Jamieson

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12750739

3 January 2024

Jeffrey C. Miller

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12750739

3 January 2024

Carl O. Pabo

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12750739

3 January 2024

language of work or name

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1 May 2003

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full work available at URL

31 July 2017

http://www.nature.com/articles/nrd1087.pdf

file format

Portable Document Format

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http://www.nature.com/articles/nrd1087

3 January 2024

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Nature Reviews Drug Discovery

3 January 2024

published in

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31 July 2017

volume

2

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31 July 2017

issue

5

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31 July 2017

page(s)

361-368

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Expressing the human genome

31 July 2017

cites work

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Proposed structure for the zinc-binding domains from transcription factor IIIA and related proteins

31 March 2020

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Three-dimensional solution structure of a single zinc finger DNA-binding domain

31 March 2020

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Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

31 March 2020

1 reference

Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator

31 March 2020

1 reference

Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex

31 March 2020

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The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition

31 March 2020

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Zinc finger phage: affinity selection of fingers with new DNA-binding specificities

31 March 2020

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In vitro selection of zinc fingers with altered DNA-binding specificity

31 March 2020

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Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage

31 March 2020

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DNA recognition by Cys2His2 zinc finger proteins

31 March 2020

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Surface presentation of protein epitopes using bacteriophage expression systems

31 March 2020

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Phage display methods for selecting zinc finger proteins with novel DNA-binding specificities

31 March 2020

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Synergy between adjacent zinc fingers in sequence-specific DNA recognition

31 March 2020

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Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers

31 March 2020

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Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

31 March 2020

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Development of zinc finger domains for recognition of the 5'-ANN-3' family of DNA sequences and their use in the construction of artificial transcription factors

31 March 2020

1 reference

Engineering polydactyl zinc-finger transcription factors

31 March 2020

1 reference

Design and selection of novel Cys2His2 zinc finger proteins

31 March 2020

1 reference

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions

31 March 2020

1 reference

A zinc finger directory for high-affinity DNA recognition

31 March 2020

1 reference

Validated zinc finger protein designs for all 16 GNN DNA triplet targets

31 March 2020

1 reference

Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A.

31 March 2020

1 reference

Synthetic zinc finger transcription factor action at an endogenous chromosomal site. Activation of the human erythropoietin gene

31 March 2020

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Positive and negative regulation of endogenous genes by designed transcription factors

31 March 2020

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A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

31 March 2020

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A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

31 March 2020

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A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions

31 March 2020

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Scanning the human genome with combinatorial transcription factor libraries.

31 March 2020

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Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

31 March 2020

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Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants.

31 March 2020

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Distinctive DNA conformation with enlarged major groove is found in Zn-finger-DNA and other protein-DNA complexes

31 March 2020

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Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units

31 March 2020

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Structure-based design of a dimeric zinc finger protein.

31 March 2020

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Combining structure-based design with phage display to create new Cys(2)His(2) zinc finger dimers

31 March 2020

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Chemically regulated zinc finger transcription factors

31 March 2020

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Nuclease hypersensitive sites in chromatin

31 March 2020

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Cytosine methylation targetted to pre-determined sequences

31 March 2020

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Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain

31 March 2020

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A short amino acid sequence able to specify nuclear location

31 March 2020

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GAL4-VP16 is an unusually potent transcriptional activator

31 March 2020

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Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.

31 March 2020

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Conserved KRAB protein domain identified upstream from the zinc finger region of Kox 8

31 March 2020

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Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors

31 March 2020

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PPARgamma knockdown by engineered transcription factors: exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis

31 March 2020

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Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene

31 March 2020

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31 March 2020

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Nuclear hormone receptors and gene expression

31 March 2020

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Biotechnologies and therapeutics: chromatin as a target.

31 March 2020

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Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

31 March 2020

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Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

31 March 2020

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Induction of angiogenesis in a mouse model using engineered transcription factors

31 March 2020

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Isoforms of vascular endothelial growth factor act in a coordinate fashion To recruit and expand tumor vasculature.

31 March 2020

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A genomic view of alternative splicing

31 March 2020

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Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity

31 March 2020

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Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70

31 March 2020

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Regulation of endogenous gene expression with a small-molecule dimerizer

31 March 2020

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Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents

31 March 2020

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GM-CSF-based cancer vaccines

31 March 2020

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Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors

31 March 2020

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Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors

31 March 2020

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Chimeric restriction enzymes: what is next?

31 March 2020

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Stimulation of homologous recombination through targeted cleavage by chimeric nucleases

31 March 2020

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Chimeric nucleases stimulate gene targeting in human cells

31 March 2020

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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

31 March 2020

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DNA methylation in health and disease

31 March 2020

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Characterisation of site-biased DNA methyltransferases: specificity, affinity and subsite relationships

31 March 2020

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Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors.

31 March 2020

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Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease.

31 March 2020

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Regulation of the MDR1 gene by transcriptional repressors selected using peptide combinatorial libraries

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes

series ordinal

2

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3 January 2024

Identifiers

DOI

10.1038/NRD1087

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Dimensions Publication ID

31 July 2017

1040287926

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