Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis (Q34229344)

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English	Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis (English)

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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inferred from title

rheumatoid arthritis

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author name string

A P Cope

1

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Europe PubMed Central

PubMed publication ID

31 July 2017

M Londei

2

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Europe PubMed Central

PubMed publication ID

31 July 2017

N R Chu

3

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Europe PubMed Central

PubMed publication ID

31 July 2017

S B Cohen

4

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Europe PubMed Central

PubMed publication ID

31 July 2017

M J Elliott

5

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Europe PubMed Central

PubMed publication ID

31 July 2017

F M Brennan

6

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

R N Maini

7

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

M Feldmann

8

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Europe PubMed Central

PubMed publication ID

31 July 2017

language of work or name

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publication date

1 August 1994

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Europe PubMed Central

PubMed publication ID

31 July 2017

Journal of Clinical Investigation

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Europe PubMed Central

PubMed publication ID

31 July 2017

94

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Europe PubMed Central

PubMed publication ID

31 July 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

749-760

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Europe PubMed Central

PubMed publication ID

31 July 2017

Differential regulation of tumour necrosis factor receptors (TNF-R) by IL-4; upregulation of P55 and P75 TNF-R on synovial joint mononuclear cells.

1 reference

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6 July 2018

Tumors secreting human TNF/cachectin induce cachexia in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Effect of tumor necrosis factor alpha on mitogen-activated human B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Modulation of cytokine production by transforming growth factor-beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

The biology of cachectin/TNF--a primary mediator of the host response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Serum tumor necrosis factor levels and disease dissemination in leprosy and leishmaniasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Human tumour necrosis factors-alpha and -beta: differences in their structure, expression and biological properties.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

The role of tumor necrosis factor in allograft rejection. II. Evidence that antibody therapy against tumor necrosis factor-alpha and lymphotoxin enhances cardiac allograft survival in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Cytokine production in the rheumatoid joint: implications for treatment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

The effects of Plasmodium falciparum malaria on immune control of B lymphocytes in Gambian children

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Serum concentrations of tumour necrosis factor alpha in childhood chronic inflammatory bowel disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Anti-tumor necrosis factor antibodies suppress cell-mediated immunity in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Differences in the biological activity of TNF alpha and TNF beta correlate with their different abilities for binding to the target cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Enhanced expression of tumor necrosis factor receptor mRNA and protein in mononuclear cells isolated from rheumatoid arthritis synovial joints

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Altered lymphocyte reactivity in rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=296155

6 July 2018

Enhancement of antigen- and mitogen-induced human T lymphocyte proliferation by tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abnormalities in CD4+ T-lymphocyte subsets in inflammatory rheumatic diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in scid mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of expression of human IL-1 alpha and IL-1 beta genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The assessment of disease activity in rheumatoid arthritis using a multivariate analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies of rheumatoid synovial fluid lymphocytes. II. A comparison of their behavior with blood mononuclear cells in the autologous mixed lymphocyte reaction and response to TCGF

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immune function in severe, active rheumatoid arthritis: a relationship between peripheral blood mononuclear cell proliferation to soluble antigens and mononuclear cell subset profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-2 reverses deficient cell-mediated immune responses in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human T-cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor enhances HLA-A,B,C and HLA-DR gene expression in human tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential bioassay of interleukin 2 and interleukin 4

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral blood and synovial fluid monocyte activation in inflammatory arthritis. II. Low levels of synovial fluid and synovial tissue interferon suggest that gamma-interferon is not the primary macrophage activating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor in serum and cerebrospinal fluid of patients with multiple sclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of recombinant murine tumor necrosis factor-alpha on immune function

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumor necrosis factor-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunomodulatory properties of recombinant murine and human tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human T cells from autoimmune and normal individuals can produce tumor necrosis factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/8040330

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI117394

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

31 July 2017

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