Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. (Q34248627)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20972333%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models (English)

1 reference

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14 January 2020

1 reference

1

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William C Hahn

1 reference

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14 January 2020

11

David E Root

1 reference

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14 January 2020

12

Vicki Huff

1 reference

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14 January 2020

author name string

Ron Chen

2

1 reference

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14 January 2020

Leanne C Sayles

3

1 reference

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14 January 2020

Chenwei Lin

4

1 reference

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14 January 2020

Randal G Walker

5

1 reference

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14 January 2020

Anna K Gillespie

6

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14 January 2020

Aravind Subramanian

7

1 reference

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Gregory Hinkle

8

1 reference

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14 January 2020

Xiaoping Yang

9

1 reference

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Sakina Saif

10

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14 January 2020

E Alejandro Sweet-Cordero

14

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language of work or name

English

0 references

publication date

25 October 2010

1 reference

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Journal of Clinical Investigation

14 January 2020

published in

1 reference

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14 January 2020

volume

120

1 reference

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issue

11

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14 January 2020

page(s)

3940-3952

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Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer

14 January 2020

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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6 July 2018

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6 July 2018

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WT1 induction of mitogen-activated protein kinase phosphatase 3 represents a novel mechanism of growth suppression

6 July 2018

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6 July 2018

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6 July 2018

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Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria

6 July 2018

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6 July 2018

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6 July 2018

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Knock-in of oncogenic Kras does not transform mouse somatic cells but triggers a transcriptional response that classifies human cancers

6 July 2018

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Effects of RAS on the genesis of embryonal rhabdomyosarcoma.

6 July 2018

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Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis

6 July 2018

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6 July 2018

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6 July 2018

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The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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PML is a direct p53 target that modulates p53 effector functions

6 July 2018

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6 July 2018

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6 July 2018

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The receptor tyrosine kinase regulator Sprouty1 is a target of the tumor suppressor WT1 and important for kidney development

6 July 2018

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6 July 2018

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Mutations of the BRAF gene in human cancer

6 July 2018

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6 July 2018

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6 July 2018

1 reference

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Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses

6 July 2018

1 reference

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Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965578

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

6 July 2018

1 reference

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Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

6 July 2018

1 reference

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PML is induced by oncogenic ras and promotes premature senescence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965578

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

6 July 2018

1 reference

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Senescence of human fibroblasts induced by oncogenic Raf.

6 July 2018

1 reference

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

6 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

6 July 2018

1 reference

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Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice

6 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

6 July 2018

1 reference

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Radiation-induced cell cycle arrest compromised by p21 deficiency

6 July 2018

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Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction. A specific diagnostic assay

6 July 2018

1 reference

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ras oncogenes in human cancer: a review

6 July 2018

1 reference

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Requirement for Rac1 in a K-ras induced lung cancer in the mouse.

6 July 2018

1 reference

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A negative feedback signaling network underlies oncogene-induced senescence

28 October 2018

1 reference

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Immunohistochemical detection of WT1 protein in a variety of cancer cells

28 October 2018

1 reference

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An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965578

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2965578

Overexpression of the Wilms' tumor gene WT1 in de novo lung cancers

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20972333

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20972333

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI44165

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20972333%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20972333%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

20972333

1 reference