Human cloning: can it be made safe? (Q34278634)

1 August 2017

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title

Human cloning: can it be made safe? (English)

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1 August 2017

Paul A De Sousa

3

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Ian Wilmut

6

object named as

Ian Wilmut

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1 August 2017

Susan M Rhind

1

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1 August 2017

Jane E Taylor

2

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1 August 2017

Tim J King

4

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1 August 2017

Michelle McGarry

5

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1 August 2017

publication date

1 November 2003

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1 August 2017

published in

Nature Reviews Genetics

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1 August 2017

volume

4

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1 August 2017

issue

11

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1 August 2017

page(s)

855-864

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Viable offspring derived from fetal and adult mammalian cells

1 August 2017

cites work

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Human reproductive cloning: the time is near

31 March 2020

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Rhesus monkeys produced by nuclear transfer

31 March 2020

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Nuclear transfer in the rhesus monkey: practical and basic implications

31 March 2020

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Molecular correlates of primate nuclear transfer failures

31 March 2020

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Cloned rabbits produced by nuclear transfer from adult somatic cells

31 March 2020

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Embryo development and establishment of pregnancy after embryo transfer in pigs: coping with limitations in the availability of viable embryos.

31 March 2020

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Somatic cell nuclear transfer in the pig: control of pronuclear formation and integration with improved methods for activation and maintenance of pregnancy.

31 March 2020

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A mule cloned from fetal cells by nuclear transfer

31 March 2020

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Generation of fertile cloned rats by regulating oocyte activation

31 March 2020

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Nuclear transfer of adult and genetically modified fetal cells of the rat.

31 March 2020

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Large offspring syndrome in cattle and sheep

31 March 2020

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Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome

31 March 2020

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Association of in vitro fertilization with Beckwith-Wiedemann syndrome and epigenetic alterations of LIT1 and H19

31 March 2020

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Evidence for placental abnormality as the major cause of mortality in first-trimester somatic cell cloned bovine fetuses

31 March 2020

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Evaluation of gestational deficiencies in cloned sheep fetuses and placentae.

31 March 2020

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Placentomegaly in Cloned Mouse Concepti Caused by Expansion of the Spongiotrophoblast Layer1

31 March 2020

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Numerical chromosome errors in day 7 somatic nuclear transfer bovine blastocysts.

31 March 2020

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Cloned mice have an obese phenotype not transmitted to their offspring

31 March 2020

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Chromatin modification and epigenetic reprogramming in mammalian development

31 March 2020

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DNA methylation and imprinting: why bother?

31 March 2020

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Methylation and imprinting: from host defense to gene regulation?

31 March 2020

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Role for DNA methylation in genomic imprinting

31 March 2020

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Relationships between chromatin organization and DNA methylation in determining gene expression

31 March 2020

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Dynamic methylation adjustment and counting as part of imprinting mechanisms

31 March 2020

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Demethylation of the zygotic paternal genome

31 March 2020

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Active demethylation of the paternal genome in the mouse zygote

31 March 2020

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Chromosome methylation patterns during mammalian preimplantation development

31 March 2020

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Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos

31 March 2020

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Somatic cell nuclear transfer

31 March 2020

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Aberrant methylation of donor genome in cloned bovine embryos

31 March 2020

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Delayed and incomplete reprogramming of chromosome methylation patterns in bovine cloned embryos

31 March 2020

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Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos

31 March 2020

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Abnormal regulation of DNA methyltransferase expression in cloned mouse embryos

31 March 2020

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Typical demethylation events in cloned pig embryos. Clues on species-specific differences in epigenetic reprogramming of a cloned donor genome

31 March 2020

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Disruption of Imprinted Gene Methylation and Expression in Cloned Preimplantation Stage Mouse Embryos1

31 March 2020

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Gametic imprinting in mammals

31 March 2020

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Clinical, hormonal, and hematologic characteristics of bovine calves derived from nuclei from somatic cells

31 March 2020

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Cloned lambs--lessons from pathology

31 March 2020

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Improving the safety of embryo technologies: possible role of genomic imprinting

31 March 2020

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Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture

31 March 2020

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Epigenetic instability in ES cells and cloned mice

31 March 2020

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X-chromosome inactivation: counting, choice and initiation

31 March 2020

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X-Chromosome inactivation in cloned mouse embryos

31 March 2020

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In vitro production and nuclear transfer affect dosage compensation of the X-linked gene transcripts G6PD, PGK, and Xist in preimplantation bovine embryos

31 March 2020

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Comparison of gene transcription in cloned bovine embryos produced by different nuclear transfer techniques

31 March 2020

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Oct4 distribution and level in mouse clones: consequences for pluripotency

31 March 2020

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Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

31 March 2020

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Oct-4: gatekeeper in the beginnings of mammalian development.

31 March 2020

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Nuclear transfer protocol affects messenger RNA expression patterns in cloned bovine blastocysts

31 March 2020

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Analysis of telomere lengths in cloned sheep

31 March 2020

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Cloning of mice to six generations

31 March 2020

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Extension of cell life-span and telomere length in animals cloned from senescent somatic cells

31 March 2020

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Normal telomere lengths found in cloned cattle

31 March 2020

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Remarkable differences in telomere lengths among cloned cattle derived from different cell types.

31 March 2020

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Analysis of gene transcription in bovine nuclear transfer embryos reconstructed with granulosa cell nuclei.

31 March 2020

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The health profile of cloned animals.

31 March 2020

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Cloned Cattle Can Be Healthy and Normal

31 March 2020

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Production of cloned goats after nuclear transfer using adult somatic cells

31 March 2020

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Stage-specific appearance of the mouse antigen TEC-3 in normal and nuclear transfer bovine embryos: re-expression after nuclear transfer.

31 March 2020

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Preimplantation genetic diagnosis

31 March 2020

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Alterations of expression of developmentally important genes in preimplantation bovine embryos by in vitro culture conditions: implications for subsequent development

31 March 2020

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Genome-wide epigenetic alterations in cloned bovine fetuses

31 March 2020

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Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei

31 March 2020

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Effects of culture system and protein supplementation on mRNA expression in pre-implantation bovine embryos

31 March 2020

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Derivation of completely cell culture-derived mice from early-passage embryonic stem cells

31 March 2020

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Application of cDNA arrays to monitor mRNA profiles in single preimplantation mouse embryos.

31 March 2020

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Parallel assessment of CpG methylation by two-color hybridization with oligonucleotide arrays

31 March 2020

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Project normal: defining normal variance in mouse gene expression

31 March 2020

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Pharmacogenomics: translating functional genomics into rational therapeutics

31 March 2020

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Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer.

31 March 2020

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Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy

31 March 2020

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Homologous recombination in human embryonic stem cells.

31 March 2020

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Nuclear transplantation, embryonic stem cells, and the potential for cell therapy

31 March 2020

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Parthenogenetic stem cells in nonhuman primates.

31 March 2020

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Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei

31 March 2020

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Cloning of male mice from adult tail-tip cells

31 March 2020

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Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

31 March 2020

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DNA methylation, imprinting and cancer

31 March 2020

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Adult cloning in cattle: potential of nuclei from a permanent cell line and from primary cultures

31 March 2020

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Production of cloned calves following nuclear transfer with cultured adult mural granulosa cells

31 March 2020

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Production of calves by transfer of nuclei from cultured somatic cells obtained from Japanese black bulls

31 March 2020

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Cloned pigs produced by nuclear transfer from adult somatic cells

31 March 2020

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Clinical and pathologic features of cloned transgenic calves and fetuses (13 case studies).

31 March 2020

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Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning.

31 March 2020

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Cloned transgenic calves produced from nonquiescent fetal fibroblasts

31 March 2020

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Early death of mice cloned from somatic cells

31 March 2020

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Production of gene-targeted sheep by nuclear transfer from cultured somatic cells

31 March 2020

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Cloning of calves from various somatic cell types of male and female adult, newborn and fetal cows

31 March 2020

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Deletion of the alpha(1,3)galactosyl transferase (GGTA1) gene and the prion protein (PrP) gene in sheep

31 March 2020

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Lymphoid hypoplasia and somatic cloning

31 March 2020

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Nuclear transfer in cattle using colostrum-derived mammary gland epithelial cells and ear-derived fibroblast cells

31 March 2020

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Development rates of male bovine nuclear transfer embryos derived from adult and fetal cells

31 March 2020

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Obesity--a chronic health problem in cloned mice?

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG1205

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Dimensions Publication ID

1 August 2017

1004067833

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