Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid (Q34301299)

1 August 2017

title

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid (English)

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1 August 2017

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Jung H Suh

1

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1 August 2017

Swapna V Shenvi

2

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1 August 2017

Brian M Dixon

3

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1 August 2017

Honglei Liu

4

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1 August 2017

Anil K Jaiswal

5

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1 August 2017

Rui-Ming Liu

6

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1 August 2017

Tory M Hagen

7

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1 August 2017

language of work or name

English

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publication date

25 February 2004

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Proceedings of the National Academy of Sciences of the United States of America

1 August 2017

published in

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1 August 2017

volume

101

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1 August 2017

issue

10

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1 August 2017

page(s)

3381-3386

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Effects of age and caloric restriction on glutathione redox state in mice

1 August 2017

cites work

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6 July 2018

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6 July 2018

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Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

6 July 2018

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Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

28 October 2018

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The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells

28 October 2018

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Down-regulation of gamma-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging

28 October 2018

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The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes

28 October 2018

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Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

28 October 2018

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Age-associated decline in gamma-glutamylcysteine synthetase gene expression in rats.

28 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=373470

Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamylcysteine synthetase and increases intracellular glutathione levels

28 October 2018

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High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives

28 October 2018

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12 December 2020

Age changes in visceral content of glutathione in the senescence accelerated mouse (SAM)

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12 December 2020

Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives

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12 December 2020

Autophosphorylation inhibits the activity of gamma-glutamylcysteine synthetase

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12 December 2020

Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene

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12 December 2020

(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0400282101

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1 August 2017

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1 August 2017

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