Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope (Q34348303)

1 August 2017

title

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope (English)

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1 August 2017

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5

John R Mascola

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1 August 2017

7

Peter D Kwong

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1 August 2017

6

Richard Wyatt

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1 August 2017

1

Gilad Ofek

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1 August 2017

4

Hermann Katinger

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1 August 2017

Min Tang

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1 August 2017

Anna Sambor

series ordinal

3

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1 August 2017

language of work or name

English

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publication date

1 October 2004

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1 August 2017

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1 August 2017

volume

78

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1 August 2017

issue

19

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1 August 2017

page(s)

10724-10737

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Raster3D: photorealistic molecular graphics

1 August 2017

cites work

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6 July 2018

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6 July 2018

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6 July 2018

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Structural analysis of the epitope of the anti-HIV antibody 2F5 sheds light into its mechanism of neutralization and HIV fusion

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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A potent cross-clade neutralizing human monoclonal antibody against a novel epitope on gp41 of human immunodeficiency virus type 1.

6 July 2018

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Fine definition of the epitope on the gp41 glycoprotein of human immunodeficiency virus type 1 for the neutralizing monoclonal antibody 2F5.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Role of the membrane-proximal domain in the initial stages of human immunodeficiency virus type 1 envelope glycoprotein-mediated membrane fusion.

6 July 2018

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6 July 2018

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A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

6 July 2018

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6 July 2018

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A broadly neutralizing human monoclonal antibody against gp41 of human immunodeficiency virus type 1.

6 July 2018

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A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

6 July 2018

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Protection against HIV-1 infection in hu-PBL-SCID mice by passive immunization with a neutralizing human monoclonal antibody against the gp120 CD4-binding site.

6 July 2018

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Epitope exposure on functional, oligomeric HIV-1 gp41 molecules

6 July 2018

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Generation of Human Monoclonal Antibodies against HIV-1 Proteins; Electrofusion and Epstein-Barr Virus Transformation for Peripheral Blood Lymphocyte Immortalization

6 July 2018

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Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.

6 July 2018

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Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS.

6 July 2018

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Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody

6 July 2018

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Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

6 July 2018

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Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients

6 July 2018

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6 July 2018

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6 July 2018

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Structure-affinity relationships in the gp41 ELDKWA epitope for the HIV-1 neutralizing monoclonal antibody 2F5: effects of side-chain and backbone modifications and conformational constraints

6 July 2018

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Construction of recombinant targeting immunogens incorporating an HIV-1 neutralizing epitope into sites of differing conformational constraint

27 October 2018

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Stable recombinant expression of the anti HIV-1 monoclonal antibody 2F5 after IgG3/IgG1 subclass switch in CHO cells

27 October 2018

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12 December 2020

Epitope-vaccine induces high levels of ELDKWA-epitope-specific neutralizing antibody

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12 December 2020

Induction of high level of specific antibody response to the neutralizing epitope ELDKWA on HIV-1 gp41 by peptide-vaccine

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12 December 2020

HIV-1 vaccine development: constrained peptide immunogens show improved binding to the anti-HIV-1 gp41 MAb

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

Restricted antigenic variability of the epitope recognized by the neutralizing gp41 antibody 2F5

1 reference

12 December 2020

Molecular Characterization of Five Neutralizing Anti-HIV Type 1 Antibodies: Identification of Nonconventional D Segments in the Human Monoclonal Antibodies 2G12 and 2F5

1 reference

12 December 2020

10.1128/JVI.78.19.10724-10737.2004

Identifiers

DOI

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1 August 2017

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1 August 2017

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