Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair (Q34365755)

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English	Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair	scientific article

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Europe PubMed Central

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1 August 2017

Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair (English)

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1 August 2017

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Peng Lv

1

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1 August 2017

Yue Wang

2

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1 August 2017

Jie Ma

3

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1 August 2017

Zheng Wang

4

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1 August 2017

Jing-Li Li

5

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1 August 2017

Christopher S Hong

6

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1 August 2017

Zhengping Zhuang

7

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1 August 2017

Yi-Xin Zeng

8

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1 August 2017

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1 September 2014

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1 August 2017

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1 August 2017

5

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1 August 2017

17

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1 August 2017

7512-7524

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Europe PubMed Central

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1 August 2017

Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair

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Exploiting protein phosphatase inhibitors based on cantharidin analogues for cancer drug discovery.

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Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia

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Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor

1 reference

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Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management

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Growth of the pancreatic cancer cell line PANC-1 is inhibited by protein phosphatase 2A inhibitors through overactivation of the c-Jun N-terminal kinase pathway

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Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice

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6 July 2018

Phosphatases: providing safe passage through mitotic exit

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Pharmacologic modulation of serine/threonine phosphorylation highly sensitizes PHEO in a MPC cell and mouse model to conventional chemotherapy

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Phosphorylation of TCTP as a marker for polo-like kinase-1 activity in vivo.

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Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase

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Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response

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An overview of Cdk1-controlled targets and processes

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The effect of a PP2A inhibitor on the nuclear receptor corepressor pathway in glioma

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6 July 2018

A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair

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6 July 2018

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

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PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.

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The genetics of the p53 pathway, apoptosis and cancer therapy

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Recent advances in p53 research: an interdisciplinary perspective.

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

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Protein phosphatase 2A regulatory subunits and cancer.

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6 July 2018

Living on a break: cellular senescence as a DNA-damage response

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6 July 2018

Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China

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6 July 2018

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

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Multiple pathways regulated by the tumor suppressor PP2A in transformation

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6 July 2018

Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint

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TCTP protects from apoptotic cell death by antagonizing bax function

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6 July 2018

Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.

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6 July 2018

Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner

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CIP2A inhibits PP2A in human malignancies

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PP2A: unveiling a reluctant tumor suppressor

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A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type-specific manner

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Choice of Plk1 docking partners during mitosis and cytokinesis is controlled by the activation state of Cdk1

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The complexity of p53 stabilization and activation

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6 July 2018

Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint

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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

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Global cancer statistics, 2002

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Translationally controlled tumor protein is a target of tumor reversion

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Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

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Cell death by mitotic catastrophe: a molecular definition

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[Gefitinib enhances the radiosensitivity of nasopharyngeal carcinoma cell line CNE2 in vitro]

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[Abrogation of radiation-induced G2 arrest and radiosensitization by 7-hydroxystaurosporine (UCN-01) in human nasopharyngeal carcinoma cell line]

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Nasopharyngeal carcinoma treated with reduced-volume intensity-modulated radiation therapy: report on the 3-year outcome of a prospective series

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Identifiers

10.18632/ONCOTARGET.2258

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Europe PubMed Central

PubMed publication ID

1 August 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

1 August 2017

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