Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis (Q34360732)

1 August 2017

title

Cerivastatin in vitro metabolism by CYP2C8 variants found in patients experiencing rhabdomyolysis (English)

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1 August 2017

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6

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1 August 2017

9

Bruce M Psaty

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1 August 2017

8

Susan R Heckbert

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1 August 2017

Rüdiger Kaspera

1

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1 August 2017

Suresh B Naraharisetti

2

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1 August 2017

Bani Tamraz

3

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1 August 2017

Tariku Sahele

4

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1 August 2017

Matthew J Cheesman

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1 August 2017

Kristin Marciante

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1 August 2017

Rheem A Totah

10

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1 August 2017

publication date

1 October 2010

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Pharmacogenetics and Genomics

1 August 2017

published in

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1 August 2017

volume

20

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1 August 2017

issue

10

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1 August 2017

page(s)

619-629

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Human liver expression of CYP2C8: gender, age, and genotype effects

1 August 2017

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Potential for conflict of interest in the evaluation of suspected adverse drug reactions: use of cerivastatin and risk of rhabdomyolysis

6 July 2018

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6 July 2018

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6 July 2018

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Polymorphism in CYP2C8 is associated with reduced plasma concentrations of repaglinide

6 July 2018

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6 July 2018

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Gemfibrozil greatly increases plasma concentrations of cerivastatin

6 July 2018

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6 July 2018

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Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism

6 July 2018

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Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid.

6 July 2018

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6 July 2018

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6 July 2018

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Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

6 July 2018

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Metabolism of cerivastatin by human liver microsomes in vitro. Characterization of primary metabolic pathways and of cytochrome P450 isozymes involved

6 July 2018

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6 July 2018

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Benzylic oxidation of gemfibrozil-1-O-beta-glucuronide by P450 2C8 leads to heme alkylation and irreversible inhibition.

6 July 2018

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27 October 2018

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Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids

27 October 2018

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Characterization of novel CYP2C8 haplotypes and their contribution to paclitaxel and repaglinide metabolism

27 October 2018

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Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

27 October 2018

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Clearance rates of cerivastatin metabolites in a patient with cerivastatin-induced rhabdomyolysis

27 October 2018

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A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin

27 October 2018

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Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

27 October 2018

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Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A.

27 October 2018

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Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2993694

CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6α-hydroxylase activity in human liver microsomes

27 October 2018

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12 December 2020

The high-level expression in Escherichia coli of the membrane-bound form of human and rat cytochrome b5 and studies on their mechanism of function

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12 December 2020

Expression of a functional 78,000 dalton mammalian flavoprotein, NADPH-cytochrome P-450 oxidoreductase, in Escherichia coli

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12 December 2020

Effect of itraconazole on cerivastatin pharmacokinetics

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12 December 2020

Pharmacokinetics and pharmacodynamics of rosiglitazone in relation to CYP2C8 genotype

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12 December 2020

10.1097/FPC.0B013E32833ECACE

Identifiers

DOI

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1 August 2017

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1 August 2017

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