Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency (Q34396785)

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English	Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency	scientific article

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16 February 2020

Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency (English)

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16 February 2020

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folate deficiency

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Martha S. Field

1

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16 February 2020

Simon G Lamarre

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16 February 2020

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Elena Kamynina

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16 February 2020

Olufunmilayo C Agunloye

3

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16 February 2020

Rebecca P Liebenthal

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16 February 2020

Margaret E Brosnan

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16 February 2020

John T Brosnan

7

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16 February 2020

Patrick J Stover

8

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16 February 2020

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11 September 2014

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16 February 2020

Journal of Biological Chemistry

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16 February 2020

289

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16 February 2020

43

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16 February 2020

29642-29650

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A novel tumor suppressor function of glycine N-methyltransferase is independent of its catalytic activity but requires nuclear localization

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Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.

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Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration

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6 July 2018

Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis

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Competition between sumoylation and ubiquitination of serine hydroxymethyltransferase 1 determines its nuclear localization and its accumulation in the nucleus

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6 July 2018

Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice

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Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.

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Shmt1 heterozygosity impairs folate-dependent thymidylate synthesis capacity and modifies risk of Apc(min)-mediated intestinal cancer risk.

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6 July 2018

Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice

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6 July 2018

Mthfd1 is a modifier of chemically induced intestinal carcinogenesis

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Compartmentalization of Mammalian folate-mediated one-carbon metabolism

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A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repair

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Mechanism of the internal ribosome entry site-mediated translation of serine hydroxymethyltransferase 1.

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6 July 2018

SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis

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6 July 2018

Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview

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Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism

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6 July 2018

Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice

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Evidence for small ubiquitin-like modifier-dependent nuclear import of the thymidylate biosynthesis pathway

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Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses

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Substrate flux through methylenetetrahydrofolate dehydrogenase: predicted effects of the concentration of methylenetetrahydrofolate on its partitioning into pathways leading to nucleotide biosynthesis or methionine regeneration.

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