Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity (Q34416920)

2 August 2017

title

Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity (English)

1 reference

2 August 2017

0 references

3

Arne Holmgren

1 reference

2 August 2017

Jianguo Fang

1

1 reference

2 August 2017

Jun Lu

series ordinal

2

1 reference

2 August 2017

language of work or name

English

0 references

publication date

6 May 2005

1 reference

Journal of Biological Chemistry

2 August 2017

published in

1 reference

2 August 2017

volume

280

1 reference

2 August 2017

issue

26

1 reference

2 August 2017

page(s)

25284-25290

1 reference

Biological properties of curcumin-cellular and molecular mechanisms of action

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Inhibition of human low density lipoprotein oxidation by active principles from spices

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Effect of curcumin on cell cycle progression and apoptosis in vascular smooth muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Recent studies on the biofunctions and biotransformations of curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Curcumin induces apoptosis in human breast cancer cells through p53-dependent Bax induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

The thioredoxin system—From science to clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Physiological functions of thioredoxin and thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Structure and mechanism of mammalian thioredoxin reductase: the active site is a redox-active selenolthiol/selenenylsulfide formed from the conserved cysteine-selenocysteine sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Three-dimensional structure of a mammalian thioredoxin reductase: implications for mechanism and evolution of a selenocysteine-dependent enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Thioredoxin reductase as a pathophysiological factor and drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Oxidation of thioredoxin reductase in HeLa cells stimulated with tumor necrosis factor-alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Curcumin selectively induces apoptosis in deregulated cyclin D1-expressed cells at G2 phase of cell cycle in a p53-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Antioxidant function of thioredoxin and glutaredoxin systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

NK-lysin, a disulfide-containing effector peptide of T-lymphocytes, is reduced and inactivated by human thioredoxin reductase. Implication for a protective mechanism against NK-lysin cytotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Inactivation of protein disulfide isomerase by alkylators including alpha,beta-unsaturated aldehydes at low physiological pHs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Curcumin impairs tumor suppressor p53 function in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Gene expression and the thiol redox state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Reduction of dehydroascorbate to ascorbate by the selenoenzyme thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Curcumin-induced histone hypoacetylation: the role of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Pharmacology of Curcuma longa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

The emerging role of reactive oxygen species in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

ROS stress in cancer cells and therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414645200

21 January 2018

Identifiers

DOI

10.1074/JBC.M414645200

1 reference

2 August 2017

1 reference