Use of human tissue in ADME and safety profiling of development candidates (Q34418126)

2 August 2017

title

Use of human tissue in ADME and safety profiling of development candidates (English)

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2 August 2017

Robert A. Coleman

1

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2 August 2017

Wayne P. Bowen

2

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2 August 2017

Ian A. Baines

3

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2 August 2017

Amanda J. Woodrooffe

4

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2 August 2017

Anthony M. Brown

5

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2 August 2017

publication date

1 November 2001

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2 August 2017

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2 August 2017

volume

6

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2 August 2017

issue

21

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2 August 2017

page(s)

1116-1126

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Methods of Investigating Intestinal Transport

2 August 2017

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Species-specific differences in taxol transport and cytotoxicity against human and rodent tumor cells. Evidence for an alternate transport system

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Human intestinal permeability

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N-oxidation of irsogladine by the CYP2C subfamily in the rat, dog, monkey and man

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Interspecies variability and drug interactions of clozapine metabolism by microsomes

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Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin

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Screening for human ADME/Tox drug properties in drug discovery

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7 January 2021

Cryopreserved human hepatocytes: characterization of drug-metabolizing enzyme activities and applications in higher throughput screening assays for hepatotoxicity, metabolic stability, and drug-drug interaction potential

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7 January 2021

Long-term primary cultures of adult human hepatocytes

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7 January 2021

The role of individual human cytochromes P450 in drug metabolism and clinical response

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Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells

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7 January 2021

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Hepatotoxicity caused by the combined action of isoniazid and rifampicin

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Effects of anticonvulsant agents on halothane-induced liver injury in human subjects and experimental animals

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7 January 2021

A study of interaction of a low-dose combination oral contraceptive with anti-tubercular drugs

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7 January 2021

Interactions between clinically used drugs and oral contraceptives

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7 January 2021

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Proteomics as a tool in the pharmaceutical drug design process

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7 January 2021

Two-dimensional gel electrophoresis: a powerful method to elucidate cellular responses to toxic compounds

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7 January 2021

Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors.

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7 January 2021

Screening lead compounds for QT interval prolongation

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7 January 2021

Atropine Inhibition of Echothiophate Cataractogenesis in Monkeys

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7 January 2021

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Identifiers

DOI

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2 August 2017

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