Diabetes mellitus and genetically programmed defects in beta-cell function (Q34462316)

2 August 2017

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title

Diabetes mellitus and genetically programmed defects in beta-cell function (English)

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2 August 2017

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Bell GI

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2 August 2017

Polonsky KS

2

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2 August 2017

language of work or name

English

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publication date

1 December 2001

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2 August 2017

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2 August 2017

volume

414

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2 August 2017

issue

6865

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2 August 2017

page(s)

788-791

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Type 1 diabetes: new perspectives on disease pathogenesis and treatment

2 August 2017

cites work

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7 January 2021

Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

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7 January 2021

Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

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7 January 2021

Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

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7 January 2021

Genetically defined forms of diabetes in children

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7 January 2021

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

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7 January 2021

Neonatal diabetes mellitus due to complete glucokinase deficiency

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7 January 2021

Liver-enriched transcription factors and hepatocyte differentiation.

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7 January 2021

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences

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7 January 2021

Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene

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7 January 2021

Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta

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7 January 2021

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

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7 January 2021

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

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7 January 2021

Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

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7 January 2021

Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene

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7 January 2021

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

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7 January 2021

Insulin-promoter-factor 1 is required for pancreas development in mice

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7 January 2021

Transcribing pancreas.

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7 January 2021

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

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7 January 2021

Purification of the beta-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

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7 January 2021

Early-onset type-II diabetes mellitus (MODY4) linked to IPF1

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7 January 2021

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

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7 January 2021

Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

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7 January 2021

Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

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7 January 2021

BETA2 and pancreatic islet development

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7 January 2021

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

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7 January 2021

Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history

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7 January 2021

Maternally inherited diabetes and deafness: a new diabetes subtype

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7 January 2021

Clinical phenotypes, insulin secretion, and insulin sensitivity in kindreds with maternally inherited diabetes and deafness due to mitochondrial tRNALeu(UUR) gene mutation

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7 January 2021

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

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7 January 2021

Type 2 diabetes mellitus in children: primary care and public health considerations

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7 January 2021

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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7 January 2021

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids

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7 January 2021

Changes in pancreatic islet glucokinase and hexokinase activities with increasing age, obesity, and the onset of diabetes

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7 January 2021

Evidence for a circulating islet cell growth factor in insulin-resistant states

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7 January 2021

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

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7 January 2021

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

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7 January 2021

Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes

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7 January 2021

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

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7 January 2021

Evidence for gene-nutrient interaction at the PPARgamma locus.

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7 January 2021

Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene

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7 January 2021

Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists

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7 January 2021

Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance

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7 January 2021

Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells

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7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

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7 January 2021

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

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7 January 2021

Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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7 January 2021

A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

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7 January 2021

Calpains play a role in insulin secretion and action

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7 January 2021

A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q

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7 January 2021

Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes

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7 January 2021

Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice

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7 January 2021

Identifiers

DOI

10.1038/414788A

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Dimensions Publication ID

2 August 2017

1021734378

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