Mitochondrial function in normal and diabetic beta-cells (Q34462332)

2 August 2017

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title

Mitochondrial function in normal and diabetic beta-cells (English)

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2 August 2017

Maechler P

1

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2 August 2017

Wollheim CB

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

1 December 2001

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2 August 2017

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2 August 2017

volume

414

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2 August 2017

issue

6865

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2 August 2017

page(s)

807-812

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Mitochondrial diseases in man and mouse

2 August 2017

cites work

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7 January 2021

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

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7 January 2021

Mitochondrial evolution

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Protein import into mitochondria

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Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

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The free radical theory of aging matures

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Role of calcium ions in regulation of mammalian intramitochondrial metabolism

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Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death

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Metabolic coupling factors in pancreatic beta-cell signal transduction

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7 January 2021

Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm

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Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells

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7 January 2021

Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

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7 January 2021

Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes

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Stimulus-secretion coupling in pancreatic beta cells.

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The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint

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Familial persistent hyperinsulinemic hypoglycemia of infancy and mutations in the sulfonylurea receptor

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Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations

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7 January 2021

Triggering and amplifying pathways of regulation of insulin secretion by glucose

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Rapid ATP-Dependent Priming of Secretory Granules Precedes Ca2+-Induced Exocytosis in Mouse Pancreatic B-Cells

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7 January 2021

Concentration dependence and time course of the effects of glucose on adenine and guanine nucleotides in mouse pancreatic islets

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7 January 2021

Regulation of exocytosis in electrically permeabilized insulin-secreting cells. Evidence for Ca2+ dependent and independent secretion

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7 January 2021

Ca(2+)- and GTP-dependent exocytosis in mouse pancreatic beta-cells involves both common and distinct steps.

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7 January 2021

The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis.

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Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus

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Glucagon receptors on human islet cells contribute to glucose competence of insulin release

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Regulation of insulin secretion by cAMP in rat islets of Langerhans permeabilised by high-voltage discharge

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7 January 2021

Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic beta cells.

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7 January 2021

cAMP-GEFII is a direct target of cAMP in regulated exocytosis

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7 January 2021

Separation of the glucose-stimulated cytoplasmic and mitochondrial NAD(P)H responses in pancreatic islet beta cells

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7 January 2021

Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).

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Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion. A re-evaluation of the long-chain acyl-CoA hypothesis.

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Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.

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Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell

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Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

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7 January 2021

GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.

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7 January 2021

Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell

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7 January 2021

The stimulus-secretion coupling of glucose-induced insulin release. XXXV. The links between metabolic and cationic events

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Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

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Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in a mouse pancreatic beta cell line, MIN6.

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7 January 2021

Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.

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7 January 2021

Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas

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Ethidium bromide-induced inhibition of mitochondrial gene transcription suppresses glucose-stimulated insulin release in the mouse pancreatic beta-cell line betaHC9.

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7 January 2021

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

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Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

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Mutation in mitochondrial tRNALeu(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness

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A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.

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7 January 2021

Molecular and clinical aspects of mitochondrial diabetes mellitus

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7 January 2021

A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

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7 January 2021

In situ characterization of islets in diabetes with a mitochondrial DNA mutation at nucleotide position 3243

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7 January 2021

Molecular and histological evaluation of pancreata from patients with a mitochondrial gene mutation associated with impaired insulin secretion

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7 January 2021

Diabetes mellitus associated with the 3243 mitochondrial tRNA(Leu)(UUR) mutation: insulin secretion and sensitivity

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7 January 2021

Altered mitochondrial function in fibroblasts containing MELAS or MERRF mitochondrial DNA mutations.

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7 January 2021

Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease.

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7 January 2021

A calcium signaling defect in the pathogenesis of a mitochondrial DNA inherited oxidative phosphorylation deficiency

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7 January 2021

Genetic determinants of type 2 diabetes

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7 January 2021

Seminars in Medicine of the Beth Israel Hospital, Boston. Non-insulin-dependent diabetes mellitus - a genetically programmed failure of the beta cell to compensate for insulin resistance

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7 January 2021

Increased expression of mitochondrial-encoded genes in skeletal muscle of humans with diabetes mellitus

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7 January 2021

Decreased mitochondrial DNA content in peripheral blood precedes the development of non-insulin-dependent diabetes mellitus

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7 January 2021

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

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7 January 2021

Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells

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7 January 2021

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

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7 January 2021

Aging and insulin secretion

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7 January 2021

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

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7 January 2021

Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice

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7 January 2021

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

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7 January 2021

Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction

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7 January 2021

Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action

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7 January 2021

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

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7 January 2021

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.

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7 January 2021

Regulation of fatty acid homeostasis in cells: novel role of leptin

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7 January 2021

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell

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7 January 2021

Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion?

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7 January 2021

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

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7 January 2021

The effects of coenzyme Q10 treatment on maternally inherited diabetes mellitus and deafness, and mitochondrial DNA 3243 (A to G) mutation

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7 January 2021

Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA.

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7 January 2021

Identifiers

DOI

10.1038/414807A

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Dimensions Publication ID

2 August 2017

1040179145

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