Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression (Q34488948)

2 August 2017

title

Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression (English)

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Cyclin-dependent kinase 4 Dmel_CG5072

2 August 2017

0 references

1 reference

GOA release 2020-03-11

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GOA release 2020-03-11

author name string

Meyer CA

1

1 reference

2 August 2017

Jacobs HW

2

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2 August 2017

Datar SA

3

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2 August 2017

Du W

4

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2 August 2017

Edgar BA

5

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2 August 2017

Lehner CF

6

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2 August 2017

language of work or name

English

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publication date

1 September 2000

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2 August 2017

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2 August 2017

volume

19

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2 August 2017

issue

17

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2 August 2017

page(s)

4533-4542

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The Drosophila cyclin D-Cdk4 complex promotes cellular growth

2 August 2017

cites work

1 reference

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6 July 2018

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

6 July 2018

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

6 July 2018

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6 July 2018

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

6 July 2018

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CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Novel members of the cdc2-related kinase family in Drosophila: cdk4/6, cdk5, PFTAIRE, and PITSLRE kinase

6 July 2018

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Myc and Max homologs in Drosophila

6 July 2018

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Shared role of the pRB-related p130 and p107 proteins in limb development

6 July 2018

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RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila

6 July 2018

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6 July 2018

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Cyclin D1 is a nuclear protein required for cell cycle progression in G1

6 July 2018

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Analysis of genetic mosaics in developing and adult Drosophila tissues

6 July 2018

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Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts

6 July 2018

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Distinct roles for cyclin-dependent kinases in cell cycle control

6 July 2018

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Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

6 July 2018

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DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1

6 July 2018

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Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

6 July 2018

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G1 phase progression: cycling on cue

6 July 2018

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Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

6 July 2018

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Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity.

6 July 2018

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The retinoblastoma protein and cell cycle control

6 July 2018

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Cyclin D1 provides a link between development and oncogenesis in the retina and breast

6 July 2018

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Growth suppression by p16ink4 requires functional retinoblastoma protein

6 July 2018

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Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

6 July 2018

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Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1

6 July 2018

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Gene disruptions using P transposable elements: an integral component of the Drosophila genome project

6 July 2018

1 reference

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Functional cDNA libraries from Drosophila embryos

6 July 2018

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Requirement for a functional Rb-1 gene in murine development

6 July 2018

1 reference

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Effects of an Rb mutation in the mouse

6 July 2018

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Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

6 July 2018

1 reference

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PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development.

6 July 2018

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Regulation of postembryonic G(1) cell cycle progression in Caenorhabditis elegans by a cyclin D/CDK-like complex

27 October 2018

1 reference

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Drosophila myc regulates cellular growth during development.

27 October 2018

1 reference

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Drosophila S6 kinase: a regulator of cell size

27 October 2018

1 reference

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

27 October 2018

1 reference

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Role of the INK4a locus in tumor suppression and cell mortality.

27 October 2018

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Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation.

27 October 2018

1 reference

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Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression

27 October 2018

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12 December 2020

Phosphorylation of the retinoblastoma protein is modulated in mouse kidney cells infected with polyomavirus

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12 December 2020

Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16

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12 December 2020

Tumor induction and tissue atrophy in mice lacking E2F-1

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12 December 2020

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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12 December 2020

Targeted disruption of p107: functional overlap between p107 and Rb

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12 December 2020

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

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12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.17.4533

1 reference

2 August 2017

1 reference

2 August 2017

1 reference