ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling (Q34495193)

2 August 2017

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title

ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling (English)

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2 August 2017

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Alexis Gautreau

1

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Daniel Louvard

series ordinal

2

object named as

Daniel Louvard

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2 August 2017

Monique Arpin

3

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2 August 2017

publication date

1 February 2002

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Current Opinion in Cell Biology

2 August 2017

published in

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2 August 2017

volume

14

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2 August 2017

issue

1

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2 August 2017

page(s)

104-109

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The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association

2 August 2017

cites work

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7 January 2021

A dual involvement of the amino-terminal domain of ezrin in F- and G-actin binding.

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7 January 2021

Merlin differentially associates with the microtubule and actin cytoskeleton

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7 January 2021

ERM-Merlin and EBP50 protein families in plasma membrane organization and function

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7 January 2021

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

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7 January 2021

Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets

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7 January 2021

Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures

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https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts

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7 January 2021

Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases

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https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and polyphosphatidylinositides

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7 January 2021

Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane

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7 January 2021

Protein phosphatase 2C inactivates F-actin binding of human platelet moesin

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7 January 2021

Unopposed phosphatase action initiates ezrin dysfunction: a potential mechanism for anoxic injury

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7 January 2021

ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis

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7 January 2021

Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) binding site in the NH(2)-terminal domain of ezrin correlates with its altered cellular distribution

1 reference

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7 January 2021

Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain

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7 January 2021

The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activation

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7 January 2021

Mutations in transcript isoforms of the neurofibromatosis 2 gene in multiple human tumour types

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7 January 2021

The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

1 reference

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7 January 2021

Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

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7 January 2021

Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Direct involvement of ezrin/radixin/moesin (ERM)-binding membrane proteins in the organization of microvilli in collaboration with activated ERM proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium

1 reference

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7 January 2021

In vivo functional analysis of ezrin during mouse blastocyst formation

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7 January 2021

Cytoskeletal rearrangement during migration and activation of T lymphocytes

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7 January 2021

Radixin is involved in lamellipodial stability during nerve growth cone motility

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Interdomain binding mediates tumor growth suppression by the NF2 gene product

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cells

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Ezrin immunoreactivity is associated with increasing malignancy of astrocytic tumors but is absent in oligodendrogliomas

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Altered expression of the ERM proteins in lung adenocarcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse

1 reference

https://api.crossref.org/works/10.1016%2FS0955-0674%2801%2900300-3

7 January 2021

10.1016/S0955-0674(01)00300-3

Identifiers

DOI

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2 August 2017

1 reference