Understanding autoimmune diabetes: insights from mouse models. (Q34498188)

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6 December 2019

review article

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title

Understanding autoimmune diabetes: insights from mouse models (English)

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6 December 2019

2

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6 December 2019

author name string

Luciano Adorini

series ordinal

1

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6 December 2019

Leonard C Harrison

series ordinal

3

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6 December 2019

publication date

1 January 2002

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Trends in Molecular Medicine

6 December 2019

published in

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6 December 2019

volume

8

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6 December 2019

issue

1

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6 December 2019

page(s)

31-38

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The NOD mouse model of type 1 diabetes: as good as it gets?

6 December 2019

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Local expression of TNFalpha in neonatal NOD mice promotes diabetes by enhancing presentation of islet antigens

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Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

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HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved?

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Development of autoimmune insulitis is prevented in E alpha d but not in A beta k NOD transgenic mice

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Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A β-chain or normal I-E α-chain

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MHC-linked protection from diabetes dissociated from clonal deletion of T cells

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IL-12 administration reveals diabetogenic T cells in genetically resistant I-Ealpha-transgenic nonobese diabetic mice: resistance to autoimmune diabetes is associated with binding of Ealpha-derived peptides to the I-A(g7) molecule

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7 January 2021

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

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7 January 2021

Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs

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7 January 2021

MHC structure and autoimmune T cell repertoire development

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7 January 2021

A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice

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7 January 2021

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

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7 January 2021

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

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7 January 2021

Control of autoimmune diabetes in NOD mice by GAD expression or suppression in beta cells

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7 January 2021

Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease

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7 January 2021

Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetes

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7 January 2021

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop

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7 January 2021

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Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients

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7 January 2021

Neural network-based prediction of candidate T-cell epitopes.

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T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetes

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7 January 2021

T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin

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7 January 2021

Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.

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Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

NK T cell-induced protection against diabetes in V alpha 14-J alpha 281 transgenic nonobese diabetic mice is associated with a Th2 shift circumscribed regionally to the islets and functionally to islet autoantigen

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7 January 2021

NKT cells: facts, functions and fallacies.

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7 January 2021

Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes

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7 January 2021

Deviation of pancreas-infiltrating cells to Th2 by interleukin-12 antagonist administration inhibits autoimmune diabetes

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7 January 2021

IL-12 plays a pathologic role at the inflammatory loci in the development of diabetes in NOD mice

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7 January 2021

Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele

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7 January 2021

Increased in vitro interleukin-12 production by peripheral blood in high-risk IDDM first degree relatives

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7 January 2021

Interleukin 12 and autoimmune diabetes

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7 January 2021

Tolerance to islet autoantigens in type 1 diabetes

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7 January 2021

The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice

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7 January 2021

Activation of natural killer T cells by alpha-galactosylceramide treatment prevents the onset and recurrence of autoimmune Type 1 diabetes

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7 January 2021

An Abd transgene prevents diabetes in nonobese diabetic mice by inducing regulatory T cells

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7 January 2021

Prevention of diabetes in non-obese diabetic I-Ak transgenic mice

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7 January 2021

Direct evidence for the contribution of the unique I-ANOD to the development of insulitis in non-obese diabetic mice

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7 January 2021

Transgenic HLA-DR alpha faithfully reconstitutes IE-controlled immune functions and induces cross-tolerance to E alpha in E alpha 0 mutant mice

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7 January 2021

GLYCOSURIA AND INSULITIS IN NOD MICE EXPRESSING THE HLA-DQw6 MOLECULE

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Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice

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7 January 2021

Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules

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7 January 2021

Genetic requirements for acceleration of diabetes in non-obese diabetic mice expressing interleukin-2 in islet beta-cells

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7 January 2021

Local production of human IL-6 promotes insulitis but retards the onset of insulin-dependent diabetes mellitus in non-obese diabetic mice

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7 January 2021

Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice

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7 January 2021

Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice

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7 January 2021

TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype

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7 January 2021

A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.

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7 January 2021

Following a diabetogenic T cell from genesis through pathogenesis

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7 January 2021

Protection of nonobese diabetic mice from diabetes by gene(s) closely linked to IFN-gamma receptor loci.

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7 January 2021

Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells

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7 January 2021

10.1016/S1471-4914(01)02193-1

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11796264%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

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