The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism. (Q34490597)

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16 January 2020

title

The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism (English)

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16 January 2020

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3

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16 January 2020

author name string

Mohammed S Ullah

series ordinal

1

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16 January 2020

Andrew J Davies

series ordinal

2

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16 January 2020

language of work or name

English

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publication date

1 February 2006

1 reference

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Journal of Biological Chemistry

16 January 2020

published in

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16 January 2020

volume

281

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16 January 2020

issue

14

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16 January 2020

page(s)

9030-9037

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The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

16 January 2020

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The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells

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Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle

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Lactic acid efflux from white skeletal muscle is catalyzed by the monocarboxylate transporter isoform MCT3.

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CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression

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Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

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Fluorescence resonance energy transfer studies on the interaction between the lactate transporter MCT1 and CD147 provide information on the topology and stoichiometry of the complex in situ

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Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle

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Role of hypoxia-induced anorexia and right ventricular hypertrophy on lactate transport and MCT expression in rat muscle.

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Comparison of hypoxia transcriptome in vitro with in vivo gene expression in human bladder cancer

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A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

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The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis

21 January 2018

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Genomic structure and developmental expression of the chicken nonocarboxylate transporter MCT3 gene

21 January 2018

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Transport characteristics of HL-1 cells: a new model for the study of adenosine physiology in cardiomyocytes

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Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past

21 January 2018

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Effects of transition metals on the expression of the erythropoietin gene: further evidence that the oxygen sensor is a heme protein

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Identification of hypoxia-inducible factor 1 ancillary sequence and its function in vascular endothelial growth factor gene induction by hypoxia and nitric oxide

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The HIF pathway in cancer

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Cytosolic action of thyroid hormone leads to induction of hypoxia-inducible factor-1alpha and glycolytic genes.

21 January 2018

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