Cancer modeling in the modern era: progress and challenges (Q34520417)

2 August 2017

1 reference

title

Cancer modeling in the modern era: progress and challenges (English)

1 reference

2 August 2017

1 reference

Terry Van Dyke

1

1 reference

2 August 2017

Tyler Jacks

series ordinal

2

1 reference

2 August 2017

language of work or name

English

0 references

publication date

1 January 2002

1 reference

2 August 2017

1 reference

2 August 2017

volume

108

1 reference

2 August 2017

issue

2

1 reference

2 August 2017

page(s)

135-144

1 reference

Transgenic models of tumor development.

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Use of transgenic mice in identifying chemopreventive agents

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

The role of p53 in tumour suppression: lessons from mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Cancer as a complex genetic trait: tumor susceptibility in humans and mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Imaging brain structure and function, infection and gene expression in the body using light

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Effects of angiogenesis inhibitors on multistage carcinogenesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Turning on tumors to study cancer progression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Cancer. Improved mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Building 'validated' mouse models of human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Molecular mechanisms of tumor angiogenesis and tumor progression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Essential role for oncogenic Ras in tumour maintenance

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Mouse models of tumor development in neurofibromatosis type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Manipulating the germline: its impact on the study of carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Reversible tumorigenesis by MYC in hematopoietic lineages

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Development of a flexible and specific gene delivery system for production of murine tumor models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Expression profiling and identification of novel genes in hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Visualization of GFP-expressing tumors and metastasis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

LONGITUDINAL COHORT ANALYSIS OF LETHAL PROSTATE CANCER PROGRESSION IN TRANSGENIC MICE

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Tumor suppressor gene mutations in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Apoptosis: a link between cancer genetics and chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

High resolution computed tomography and MRI for monitoring lung tumor growth in mice undergoing radioimmunotherapy: correlation with histology

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Transgenic mouse models for tumour‐suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Atm is dispensable for p53 apoptosis and tumor suppression triggered by cell cycle dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Multicolour spectral karyotyping of mouse chromosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Mouse models dissect the role of p53 in cancer and development

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Selective inactivation of p53 facilitates mouse epithelial tumor progression without chromosomal instability

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Cancer predisposition caused by elevated mitotic recombination in Bloom mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Insights into cancer from transgenic mouse models

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

A causal role for E-cadherin in the transition from adenoma to carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Unraveling human cancer in the mouse: recent refinements to modeling and analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Visualizing the kinetics of tumor-cell clearance in living animals

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Conditional expression of fibroblast growth factor-7 in the developing and mature lung.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Primary subtype C HIV-1 infection in Harare, Zimbabwe

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Cancer susceptibility and the functions of BRCA1 and BRCA2

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Development of gene-switch transgenic mice that inducibly express transforming growth factor beta1 in the epidermis

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Bax suppresses tumorigenesis and stimulates apoptosis in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Specific protection against breast cancers by cyclin D1 ablation

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression

1 reference

https://api.crossref.org/works/10.1016%2FS0092-8674%2802%2900621-9

7 January 2021

10.1016/S0092-8674(02)00621-9

Identifiers

DOI

1 reference

2 August 2017

1 reference