DNA analogues: from supramolecular principles to biological properties (Q34522704)

2 August 2017

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title

DNA analogues: from supramolecular principles to biological properties (English)

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2 August 2017

Christian J Leumann

1

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2 August 2017

language of work or name

English

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publication date

1 April 2002

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Bioorganic & Medicinal Chemistry

2 August 2017

published in

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2 August 2017

volume

10

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2 August 2017

issue

4

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2 August 2017

page(s)

841-854

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Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

2 August 2017

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Chemical etiology of nucleic acid structure

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1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

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Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA.

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Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

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Sensible use of antisense: how to use oligonucleotides as research tools

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Two problems in antisense biotechnology: in vitro delivery and the design of antisense experiments

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Novel mechanisms for antisense-mediated regulation of gene expression

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Molecular mechanisms of action of antisense drugs

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Heterocyclic modifications of oligonucleotides and antisense technology.

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Conformationally restricted carbohydrate-modified nucleic acids and antisense technology

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Bicyclic nucleosides and conformational restriction of oligonucleotides

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2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation

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Oligonucleotide N3'-->P5' phosphoramidates as potential therapeutic agents

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Morpholino antisense oligomers: the case for an RNase H-independent structural type

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Warum pentose-und nicht hexose-nucleinsäuren? Teil III. Oligo(2′,3′-dideoxy-β-D-glucopyranosyl) nucleotide (‘homo-DNS’): Paarungesigenschaften

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Why Pentose- and Not Hexose-Nucleic Acids??. Part VII. Pyranosyl-RNA (?p-RNA?). Preliminary communication

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Pyranosyl-RNA (‘p-RNA’): NMR and Molecular-Dynamics Study of the Duplex Formed by Self-pairing of Ribopyranosyl-(C-G-A-A-T-T-C-G)

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Opposite Orientation of Backbone Inclination in Pyranosyl-RNA and Homo-DNA Correlates with Opposite Directionality of Duplex Properties

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Chemical Etiology of Nucleic Acid Structure: Comparing Pentopyranosyl-(2'→4') Oligonucleotides with RNA

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Promiscuous Watson-Crick cross-pairing within the family of pentopyranosyl (4'-->2') oligonucleotides

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7 January 2021

L-alpha-lyxopyranosyl (4'-->3') oligonucleotides: a base-pairing system containing a shortened backbone

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7 January 2021

Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-(3'-->2') oligonucleotide system

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7 January 2021

Solution structure of a HNA-RNA hybrid

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Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA

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D-Altritol Nucleic Acids (ANA): Hybridisation Properties, Stability, and Initial Structural Analysis

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7 January 2021

Synthesis and Pairing Properties of Oligonucleotides Containing 3-Hydroxy-4-hydroxymethyl-1-cyclohexanyl Nucleosides

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Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

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7 January 2021

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

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7 January 2021

LNA (Locked Nucleic Acid): An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

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7 January 2021

X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

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7 January 2021

The solution structure of a locked nucleic acid (LNA) hybridized to DNA

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7 January 2021

Solution Structure of an LNA Hybridized to DNA: NMR Study of the d(CTLGCTLTLCTLGC):d(GCAGAAGCAG) Duplex Containing Four Locked Nucleotides

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7 January 2021

The conformations of locked nucleic acids (LNA)

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2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA): synthesis and triplex-forming properties

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Potent and nontoxic antisense oligonucleotides containing locked nucleic acids

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DNA triplex structures are stabilized by the incorporation of 3'-endo blocked pyrimidine nucleosides in the Hoogsteen strand

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7 January 2021

2'-O,4'-C-methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: thermodynamic and kinetic studies.

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Triple helix formation and the antigene strategy for sequence-specific control of gene expression

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A 2′,4′-Bridged Nucleic Acid Containing 2-Pyridone as a Nucleobase: Efficient Recognition of a C⋅G Interruption by Triplex Formation with a Pyrimidine Motif

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7 January 2021

Selective recognition of a C-G base-pair in the parallel DNA triple-helical binding motif

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7 January 2021

Synthesis of Novel Bicyclo[2.2.1] Ribonucleosides: 2'-Amino- and 2'-Thio-LNA Monomeric Nucleosides

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7 January 2021

Synthesis of 2‘-Amino-LNA: A Novel Conformationally Restricted High-Affinity Oligonucleotide Analogue with a Handle

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7 January 2021

Conformationally locked nucleosides. Synthesis and hybridization properties of oligodeoxynucleotides containing 2',4'-C-bridged 2'-deoxynucleosides

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7 January 2021

The Eight Stereoisomers of LNA (Locked Nucleic Acid): A Remarkable Family of Strong RNA Binding Molecules We acknowledge the Danish Natural Science Research Council, the Danish Technical Research Council, and Exiqon A/S for financial support. Ms Bri

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7 January 2021

The adenine derivative of alpha-L-LNA (alpha-L-ribo configured locked nucleic acid): synthesis and high-affinity hybridization towards DNA, RNA, LNA and alpha-L-LNA complementary sequences

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7 January 2021

Incorporation of alpha- and beta-LNA (locked nucleic acid) monomers in oligodeoxynucleotides with polarity reversals.

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7 January 2021

Bicyclo-DNA: a Hoogsteen-selective pairing system

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7 January 2021

Ligand-induced formation of hoogsteen-paired parallel DNA.

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7 January 2021

Watson-Crick base-pairing properties of bicyclo-DNA.

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7 January 2021

Nucleosides and nucleotides. Part 5. The stereochemistry of oligonucleotides consisting of 2′-deoxy-α-d-ribosides, a study withDreiding stereomodels

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7 January 2021

alpha-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural alpha-hexadeoxyribonucleotide alpha-[d(CpApTpGpCpG)] with its beta-complement beta-[d(GpTpApCpGpC)] deduced from high field 1H-NMR.

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7 January 2021

Alpha-DNA VIII: thermodynamic parameters of complexes formed between the oligo-alpha-deoxynucleotides: alpha-d(GGAAGG) and alpha-d(CCTTCC) and their complementary oligo-beta-deoxynucleotides: beta-d(CCTTCC) and beta-d(GGAAGG) are different.

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7 January 2021

Sensitivity of splice sites to antisense oligonucleotides in vivo.

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7 January 2021

Bicyclo[3.2.1]-DNA, a new DNA analog with a rigid backbone and flexibly linked bases: pairing properties with complementary DNA.

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7 January 2021

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7 January 2021

TNA as a Potential Alternative to Natural Nucleic Acids

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7 January 2021

Ribozyme structures and mechanisms

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7 January 2021

Organization of 'nanocrystal molecules' using DNA.

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7 January 2021

A DNA-based method for rationally assembling nanoparticles into macroscopic materials

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7 January 2021

Programmed Materials Synthesis with DNA

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7 January 2021

Nucleic acid aptamers-from selection in vitro to applications in vivo

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7 January 2021

Artificial ribozymes and deoxyribozymes

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7 January 2021

PNA oligomers as tools for specific modulation of gene expression.

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7 January 2021

PNA: Synthetic Polyamide Nucleic Acids with Unusual Binding Properties

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7 January 2021

10.1016/S0968-0896(01)00348-0

Identifiers

DOI

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2 August 2017

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