Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease. (Q34541593)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20858858%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Lyn- and PLC-beta3-dependent regulation of SHP-1 phosphorylation controls Stat5 activity and myelomonocytic leukemia-like disease (English)

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14 February 2020

1 reference

1 reference

1

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14 February 2020

author name string

Tomoaki Ando

2

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14 February 2020

Huan-You Wang

3

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14 February 2020

Yuko Kawakami

4

1 reference

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14 February 2020

Toshiaki Kawakami

5

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14 February 2020

language of work or name

English

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publication date

21 September 2010

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14 February 2020

number of pages

11

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inferred from page(s)

published in

Blood

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14 February 2020

volume

116

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14 February 2020

issue

26

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14 February 2020

page(s)

6003-6013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20858858%20AND%20SRC:MED&resulttype=core&format=json

SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils.

14 February 2020

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7 July 2018

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7 July 2018

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Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates

7 July 2018

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Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

7 July 2018

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Regulation of myeloproliferation and M2 macrophage programming in mice by Lyn/Hck, SHIP, and Stat5

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.

7 July 2018

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Beta common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice

7 July 2018

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Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice

7 July 2018

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Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model

7 July 2018

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Monocyte and macrophage heterogeneity

7 July 2018

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Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI

7 July 2018

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Genetics of myeloid malignancies: pathogenetic and clinical implications

7 July 2018

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A SHPing tale: perspectives on the regulation of SHP-1 and SHP-2 tyrosine phosphatases by the C-terminal tail

7 July 2018

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

7 July 2018

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Focus on myeloproliferative diseases and myelodysplastic syndromes

7 July 2018

1 reference

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Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

7 July 2018

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Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice

7 July 2018

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Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

7 July 2018

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Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

7 July 2018

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Src homology 2-containing 5-inositol phosphatase (SHIP) suppresses an early stage of lymphoid cell development through elevated interleukin-6 production by myeloid cells in bone marrow

7 July 2018

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Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

7 July 2018

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A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling

7 July 2018

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Mechanisms of anemia in SHP-1 protein tyrosine phosphatase-deficient "viable motheaten" mice

7 July 2018

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Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity

7 July 2018

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Signal transducer and activator of transcription proteins in leukemias.

7 July 2018

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The role of C-terminal tyrosine phosphorylation in the regulation of SHP-1 explored via expressed protein ligation

7 July 2018

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STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65.

7 July 2018

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Regulation of phosphoinositide-specific phospholipase C

7 July 2018

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Nf1 and Gmcsf interact in myeloid leukemogenesis

7 July 2018

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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

7 July 2018

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Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

7 July 2018

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P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

7 July 2018

1 reference

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Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031387

Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031387

Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031387

Insulin stimulates the phosphorylation of Tyr538 and the catalytic activity of PTP1C, a protein tyrosine phosphatase with Src homology-2 domains.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031387

Phosphoinositide-phospholipase C beta1 mono-allelic deletion is associated with myelodysplastic syndromes evolution into acute myeloid leukemia.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3031387

SHIP represses the generation of alternatively activated macrophages

27 October 2018

1 reference

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Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis

27 October 2018

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

27 October 2018

1 reference

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JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.

27 October 2018

1 reference

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Effective dephosphorylation of Src substrates by SHP-1.

27 October 2018

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Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium

27 October 2018

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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

27 October 2018

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Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors

27 October 2018

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12 December 2020

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1 reference

12 December 2020

Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell

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12 December 2020

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients

1 reference

12 December 2020

Phosphoinositide phospholipase Cbeta1 (PI-PLCbeta1) gene in myelodysplastic syndromes and cytogenetically normal acute myeloid leukemia: not a deletion, but increased PI-PLCbeta1 expression is an independent prognostic factor

1 reference

12 December 2020

Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines

1 reference

12 December 2020

Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice

1 reference

12 December 2020

Stat5 activation plays a critical role in Th2 differentiation

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12 December 2020

10.1182/BLOOD-2010-05-283937

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20858858%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20858858%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

20858858

1 reference