Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding (Q34543629)

2 August 2017

title

Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding (English)

1 reference

2 August 2017

3

Donna Matzov

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2 August 2017

8

Anat Bashan

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2 August 2017

2

Itai Wekselman

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2 August 2017

9

Ada Yonath

1 reference

2 August 2017

Miri Krupkin

1

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Ella Zimmerman

series ordinal

7

object named as

Ella Zimmerman

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2 August 2017

4

Zohar Eyal

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2 August 2017

6

Haim Rozenberg

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2 August 2017

5

Yael Diskin Posner

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2 August 2017

language of work or name

English

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publication date

19 October 2016

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 August 2017

published in

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2 August 2017

volume

113

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2 August 2017

issue

44

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2 August 2017

page(s)

E6796-E6805

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Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome

2 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome

7 July 2018

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The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Novel avilamycin derivatives with improved polarity generated by targeted gene disruption

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Mutations in ribosomal protein L16 and in 23S rRNA in Enterococcus strains for which evernimicin MICs differ

21 January 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.

7 July 2018

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An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57.

7 July 2018

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Effects of mutations in ribosomal protein L16 on susceptibility and accumulation of evernimicin

7 July 2018

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Presence of variations in ribosomal protein L16 corresponding to susceptibility of enterococci to oligosaccharides (Avilamycin and evernimicin).

7 July 2018

1 reference

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Evernimicin (SCH27899) inhibits a novel ribosome target site: analysis of 23S ribosomal DNA mutants.

7 July 2018

1 reference

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Evernimicin binds exclusively to the 50S ribosomal subunit and inhibits translation in cell-free systems derived from both gram-positive and gram-negative bacteria

7 July 2018

1 reference

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Mutations in ribosomal protein L16 conferring reduced susceptibility to evernimicin (SCH27899): implications for mechanism of action.

7 July 2018

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The C-terminal subdomain (IF2 C-2) contains the entire fMet-tRNA binding site of initiation factor IF2.

7 July 2018

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 July 2018

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

7 July 2018

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7 July 2018

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7 July 2018

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Multidrug-resistant Enterococcus faecium. An untreatable nosocomial pathogen

7 July 2018

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Major trends in the microbial etiology of nosocomial infection.

7 July 2018

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Protein synthesis by ribosomes with tethered subunits.

7 July 2018

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EmtA, a rRNA methyltransferase conferring high-level evernimicin resistance

21 January 2018

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Solution structure of ribosomal protein L16 from Thermus thermophilus HB8.

21 January 2018

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Fate, occurrence, and toxicity of veterinary antibiotics in environment

21 January 2018

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A systematic study of 50S ribosomal subunit purification enabling robust crystallization

21 January 2018

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Structural rearrangements of the ribosome at the tRNA proofreading step

21 January 2018

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FERMENTATION AND ISOLATION OF EVERNINOMICIN

21 January 2018

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12 December 2020

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12 December 2020

Avilamycin, an inhibitor of the 30 S ribosomal subunits function

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12 December 2020

Isolation and structural identification of nine avilamycins

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Protein structure: experimental and theoretical aspects

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12 December 2020

Identifiers

DOI

10.1073/PNAS.1614297113

1 reference

2 August 2017

1 reference

2 August 2017

1 reference