The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells (Q34551905)

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22 December 2019

title

The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells (English)

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22 December 2019

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22 December 2019

Yusaku Nakabeppu

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22 December 2019

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Gabriele Aquilina

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22 December 2019

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Peter Macpherson

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22 December 2019

author name string

Maria Teresa Russo

1

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22 December 2019

Monica Francesca Blasi

2

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22 December 2019

Federica Chiera

3

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22 December 2019

Paolo Degan

5

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22 December 2019

Masato Furuichi

7

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22 December 2019

Peter Karran

9

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22 December 2019

Margherita Bignami

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22 December 2019

language of work or name

English

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publication date

1 January 2004

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Molecular and Cellular Biology

22 December 2019

published in

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22 December 2019

volume

24

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22 December 2019

issue

1

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22 December 2019

page(s)

465-474

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Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility

22 December 2019

cites work

1 reference

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Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes

7 July 2018

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Thymic lymphomas arising in Msh2 deficient mice display a large increase in mutation frequency and an altered mutational spectrum

7 July 2018

1 reference

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Activation of human MutS homologs by 8-oxo-guanine DNA damage

7 July 2018

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7 July 2018

DNA replication fidelity

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Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase eta.

7 July 2018

1 reference

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Specificity of DNA lesion bypass by the yeast DNA polymerase eta.

7 July 2018

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2-Hydroxy-dATP is incorporated opposite G by Escherichia coli DNA polymerase III resulting in high mutagenicity

7 July 2018

1 reference

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Mammalian DNA mismatch repair

7 July 2018

1 reference

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The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

7 July 2018

1 reference

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Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15.

7 July 2018

1 reference

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Eukaryotic DNA mismatch repair

7 July 2018

1 reference

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The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae

7 July 2018

1 reference

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A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

7 July 2018

1 reference

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Induction of microsatellite instability by oxidative DNA damage

7 July 2018

1 reference

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Characterization of distinct human endometrial carcinoma cell lines deficient in mismatch repair that originated from a single tumor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Rates of spontaneous mutation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair

7 July 2018

1 reference

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Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis

7 July 2018

1 reference

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Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct

7 July 2018

1 reference

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Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

7 July 2018

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Clues to the pathogenesis of familial colorectal cancer

7 July 2018

1 reference

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Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

7 July 2018

1 reference

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An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

7 July 2018

1 reference

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Mutator phenotypes in human colorectal carcinoma cell lines

7 July 2018

1 reference

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Intracellular localization of 8-oxo-dGTPase in human cells, with special reference to the role of the enzyme in mitochondria

7 July 2018

1 reference

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Molecular cloning and nucleotide sequence of the mutT mutator of Escherichia coli that causes A:T to C:G transversion

7 July 2018

1 reference

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Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Misalignment-mediated DNA synthesis errors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Mutagenic target for hydroxyl radicals generated in Escherichia coli mutant deficient in Mn- and Fe- superoxide dismutases and Fur, a repressor for iron-uptake systems.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Asymmetry of frameshift mutagenesis during leading and lagging-strand replication in Escherichia coli.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

The relationship between benzo[a]pyrene-induced mutagenesis and carcinogenesis in repair-deficient Cockayne syndrome group B mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Oxidative DNA damage in human lymphocytes: correlations with plasma levels of alpha-tocopherol and carotenoids.

27 October 2018

1 reference

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Mutations induced by 2-hydroxyadenine on a shuttle vector during leading and lagging strand syntheses in mammalian cells.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

DNA replication fidelity with 8-oxodeoxyguanosine triphosphate.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=303369

Mediating mismatch repair

27 October 2018

1 reference

12 December 2020

Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides. New evaluation method for mutagenesis by damaged DNA precursors in vivo

1 reference

12 December 2020

Short mononucleotide repeat sequence variability in mismatch repair-deficient cancers

1 reference

12 December 2020

Mapping of an origin of DNA replication near the transcriptional promoter of the human HPRT gene

1 reference

12 December 2020

Molecular analysis of mutations in mutator colorectal carcinoma cell lines

1 reference

12 December 2020

MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae

1 reference

12 December 2020

10.1128/MCB.24.1.465-474.2004

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673178%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14673178%20AND%20SRC:MED&resulttype=core&format=json

22 December 2019

PubMed publication ID

14673178

1 reference