Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. (Q34598626)

3 August 2017

title

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664. (English)

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3 August 2017

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10

Kunlin Jin

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3 August 2017

Veronica Galvan

1

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3 August 2017

Olivia F Gorostiza

2

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3 August 2017

Surita Banwait

3

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3 August 2017

Marina Ataie

4

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3 August 2017

Anna V Logvinova

5

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3 August 2017

Sandhya Sitaraman

6

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3 August 2017

Elaine Carlson

7

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3 August 2017

Sarah A Sagi

8

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3 August 2017

Nathalie Chevallier

9

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3 August 2017

David A Greenberg

11

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3 August 2017

Dale E Bredesen

12

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3 August 2017

language of work or name

English

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publication date

25 April 2006

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

103

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3 August 2017

issue

18

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3 August 2017

page(s)

7130-7135

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Enhanced neurogenesis in Alzheimer's disease transgenic (PDGF-APPSw,Ind) mice

3 August 2017

cites work

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Microglia and Alzheimer's disease pathogenesis

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Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes

7 July 2018

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Increased hippocampal neurogenesis in Alzheimer's disease.

7 July 2018

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Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity

7 July 2018

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Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

7 July 2018

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Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis

7 July 2018

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Alzheimer's disease is a synaptic failure

7 July 2018

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The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

7 July 2018

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The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases

7 July 2018

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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

7 July 2018

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

7 July 2018

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

7 July 2018

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

7 July 2018

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Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

7 July 2018

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

7 July 2018

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

7 July 2018

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7 July 2018

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Developments of a water-maze procedure for studying spatial learning in the rat

7 July 2018

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

7 July 2018

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Caspase cleavage of members of the amyloid precursor family of proteins

7 July 2018

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Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

21 January 2018

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Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

21 January 2018

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Caspase activation increases beta-amyloid generation independently of caspase cleavage of the beta-amyloid precursor protein (APP).

21 January 2018

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Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice.

21 January 2018

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Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease

21 January 2018

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Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

21 January 2018

1 reference

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21 January 2018

1 reference

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Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

21 January 2018

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Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease.

21 January 2018

1 reference

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A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

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Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

21 January 2018

1 reference

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26 October 2018

Identifiers

DOI

10.1073/PNAS.0509695103

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3 August 2017

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3 August 2017

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