Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells (Q34630923)

3 August 2017

title

Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells (English)

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3 August 2017

3

Jeffrey A Bluestone

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3 August 2017

Cristina Penaranda

1

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3 August 2017

Qizhi Tang

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

8 July 2011

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3 August 2017

published in

Journal of Immunology

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3 August 2017

volume

187

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3 August 2017

issue

4

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3 August 2017

page(s)

2015-2022

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Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

3 August 2017

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2-Gy whole-body irradiation significantly alters the balance of CD4+CD25−T effector cells and CD4+CD25+Foxp3+T regulatory cells in mice

7 July 2018

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

7 July 2018

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

7 July 2018

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Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

7 July 2018

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Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction

7 July 2018

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The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

7 July 2018

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Apoptosis and the homeostatic control of immune responses

7 July 2018

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CD3-specific antibodies: a portal to the treatment of autoimmunity

7 July 2018

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Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs

7 July 2018

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TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

7 July 2018

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7 July 2018

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7 July 2018

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Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala).

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy

7 July 2018

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Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival

7 July 2018

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Release of tumor necrosis factor, interleukin-2, and gamma-interferon in serum after injection of OKT3 monoclonal antibody in kidney transplant recipients

7 July 2018

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7 July 2018

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TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes

26 October 2018

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CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo

26 October 2018

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Nonmitogenic CD3 antibody reverses virally induced (rat insulin promoter-lymphocytic choriomeningitis virus) autoimmune diabetes without impeding viral clearance

26 October 2018

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Phase I trial of a humanized, Fc receptor nonbinding OKT3 antibody, huOKT3gamma1(Ala-Ala) in the treatment of acute renal allograft rejection

26 October 2018

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An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity

26 October 2018

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Essential roles of TGF-beta in anti-CD3 antibody therapy: reversal of diabetes in nonobese diabetic mice independent of Foxp3+CD4+ regulatory T cells

26 October 2018

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12 December 2020

PHASE I STUDY OF AN ENGINEERED AGLYCOSYLATED HUMANIZED CD3 ANTIBODY IN RENAL TRANSPLANT REJECTION1

1 reference

12 December 2020

Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice

1 reference

12 December 2020

Immunologic monitoring with monoclonal antibodies to human T-cell subsets

1 reference

12 December 2020

Systemic reaction to the anti-T-cell monoclonal antibody OKT3 in relation to serum levels of tumor necrosis factor and interferon-gamma [corrected]

1 reference

12 December 2020

OKT3 F(ab')2 fragments--retention of the immunosuppressive properties of whole antibody with marked reduction in T cell activation and lymphokine release

1 reference

12 December 2020

Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody

1 reference

12 December 2020

CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice

1 reference

12 December 2020

Partial TCR signals delivered by FcR-nonbinding anti-CD3 monoclonal antibodies differentially regulate individual Th subsets

1 reference

12 December 2020

Treatment with nonmitogenic anti-CD3 monoclonal antibody induces CD4+ T cell unresponsiveness and functional reversal of established experimental autoimmune encephalomyelitis

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1100713

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3 August 2017

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3 August 2017

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