The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis (Q34663662)

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English	The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

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R Uher

1

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author name string

P McGuffin

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

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publication date

14 August 2007

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Europe PubMed Central

PubMed publication ID

3 August 2017

Molecular Psychiatry

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Europe PubMed Central

PubMed publication ID

3 August 2017

13

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Europe PubMed Central

PubMed publication ID

3 August 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

131-146

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Genomics and behavior. Toward behavioral genomics.

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Strategy for investigating interactions between measured genes and measured environments

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Resolving multiple epigenetic pathways to adolescent depression

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Stressful life events, genetic liability, and onset of an episode of major depression in women

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The effect of birth-weight with genetic susceptibility on depressive symptoms in childhood and adolescence

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Genetic moderation of environmental risk for depression and anxiety in adolescent girls.

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Interaction between serotonin transporter gene variation and rearing condition in alcohol preference and consumption in female primates.

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Role of genotype in the cycle of violence in maltreated children

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Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

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Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction

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Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors

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Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder

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The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication

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Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission.

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Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice

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Vulnerability to mild predator stress in serotonin transporter knockout mice

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Medial hypothalamic 5-hydroxytryptamine (5-HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity: application of recombinant adenovirus containing 5-HT1A sequences.

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Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene

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Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice

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Effects of mild early life stress on abnormal emotion-related behaviors in 5-HTT knockout mice

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Rearing condition and rh5-HTTLPR interact to influence limbic-hypothalamic-pituitary-adrenal axis response to stress in infant macaques

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Serotonin transporter gene polymorphism, differential early rearing, and behavior in rhesus monkey neonates

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The utility of the non-human primate; model for studying gene by environment interactions in behavioral research

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Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression

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Social supports and serotonin transporter gene moderate depression in maltreated children

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Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children

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Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology.

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Life events, first depression onset and the serotonin transporter gene

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Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression.

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The risk for depression conferred by stressful life events is modified by variation at the serotonin transporter 5HTTLPR genotype: evidence from the Spanish PREDICT-Gene cohort

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Depressive symptoms in mid-pregnancy, lifetime stressors and the 5-HTTLPR genotype

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Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden

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Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene

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The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression

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Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder

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Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture

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Serotonin transporter (5-HTTLPR) genotype, childhood abuse, and suicide attempts in adult psychiatric inpatients.

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Validity of adult retrospective reports of adverse childhood experiences: review of the evidence

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Polymorphism in the serotonin transporter gene and moderators of prolactin response to meta-chlorophenylpiperazine in African-American cocaine abusers and controls

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Stress and affective disorders in humans

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Sample size determination for studies of gene-environment interaction

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A 40-year perspective on the prevalence of depression: the Stirling County Study

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Gender differences in depression. Critical review

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The influence of genetic factors and life stress on depression among adolescent girls

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Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population

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Role of the serotonin transporter gene and family function in adolescent alcohol consumption

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Genetic and environmental risk factors in adolescent substance use.

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Stressful life events and previous episodes in the etiology of major depression in women: an evaluation of the "kindling" hypothesis

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Personality and major depression: a Swedish longitudinal, population-based twin study

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Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan.

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Pstl RFLP at the SERT locus

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Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription

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Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

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Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression

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Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain

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A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.

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No association between genotype of the promoter region of serotonin transporter gene and serotonin transporter binding in human brain measured by PET.

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No evidence for in vivo regulation of midbrain serotonin transporter availability by serotonin transporter promoter gene polymorphism

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Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype

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Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR.

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A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide

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Serotonin-related gene polymorphisms and central nervous system serotonin function

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A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans

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Serotonin transporter promoter polymorphism is associated with attenuated prolactin response to fenfluramine

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Effects of serotonin transporter promoter polymorphisms on serotonin function

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Association between a serotonin transporter promoter region polymorphism and mood response during tryptophan depletion

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Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls

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The impact of tryptophan depletion and 5-HTTLPR genotype on passive avoidance and response reversal instrumental learning tasks.

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Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression

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Serotonin transporter polymorphism mediates vulnerability to loss of incentive motivation following acute tryptophan depletion

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The effects of acute tryptophan depletion and serotonin transporter polymorphism on emotional processing in memory and attention

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Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style

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A susceptibility gene for affective disorders and the response of the human amygdala

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Serotonin transporter genetic variation and the response of the human amygdala

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Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter

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5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

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Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task

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Serotonin transporter genotype (5-HTTLPR): effects of neutral and undefined conditions on amygdala activation

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Neural correlates of epigenesis

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Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle.

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The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants

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Sequence analysis of the serotonin transporter and associations with antidepressant response

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Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531.

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5-HTTLPR polymorphism of the serotonin transporter gene predicts non-remission in major depression patients treated with citalopram in a 12-weeks follow up study

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Analysis of association between the serotonin transporter and antidepressant response in a large clinical sample

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Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

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Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice

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Gender-dependent modulation of brain monoamines and anxiety-like behaviors in mice with genetic serotonin transporter and BDNF deficiencies

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Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety

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Genetic influence on life events during the last half of the life span

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Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study

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Early experience and serotonin transporter gene variation interact to influence primate CNS function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction between serotonin transporter gene, catechol-O-methyltransferase gene and stressful life events in mood disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Interactive Effects of the Serotonin Transporter 5-HTTLPR Polymorphism and Stressful Life Events on College Student Drinking and Drug Use

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Recall of psychiatric history in cross-sectional surveys: implications for epidemiologic research

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

The detection of gene–environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Sex differences in event-related risk for major depression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective serotonin reuptake inhibitors in affective disorders--I. Basic pharmacology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Organization of the human serotonin transporter gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Allelic Variation of Human Serotonin Transporter Gene Expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Population studies of polymorphisms of the serotonin transporter protein gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Glucocorticoid-regulated human serotonin transporter (5-HTT) expression is modulated by the 5-HTT gene-promotor-linked polymorphic region

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

How common is resistance to treatment in recurrent, nonpsychotic geriatric depression?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Serotonin transporter gene polymorphism and antidepressant response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Allelic variation in the serotonin transporter promoter affects onset of paroxetine treatment response in late-life depression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Time-varying exposure and the impact of stressful life events on onset of affective disorder

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Traumas and other adverse life events in adolescents with alcohol abuse and dependence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Life events and psychosis. Initial results from the Camberwell Collaborative Psychosis Study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of induced mood on self-reported life events and perceived and received social support.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Childhood adversities and adult depression: basic patterns of association in a US national survey

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Nature and nurture predispose to violent behavior: serotonergic genes and adverse childhood environment.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Serotonin transporter gene polymorphisms, alcoholism, and suicidal behavior

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

There's more to self-esteem than whether it is high or low: the importance of stability of self-esteem

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002067

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.MP.4002067

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

0 references

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