How oxygen makes its presence felt (Q34702199)

4 August 2017

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title

How oxygen makes its presence felt (English)

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4 August 2017

1

William G Kaelin

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4 August 2017

publication date

1 June 2002

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4 August 2017

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4 August 2017

volume

16

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4 August 2017

issue

12

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4 August 2017

page(s)

1441-1445

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

4 August 2017

cites work

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Characterization and comparative analysis of the EGLN gene family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

The 2-oxoglutarate binding site of prolyl 4-hydroxylase. Identification of distinct subsites and evidence for 2-oxoglutarate decarboxylation in a ligand reaction at the enzyme-bound ferrous ion

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selectively suppress cellular hydroxyprolyl biosynthesis. Decrease in interstitial collagen and Clq secretion in cell culture

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Perspectives on oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

The DNA-repair protein AlkB, EGL-9, and leprecan define new families of 2-oxoglutarate- and iron-dependent dioxygenases

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Building better vasculature

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Syncatalytic inactivation of prolyl 4-hydroxylase by anthracyclines

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1101/GAD.1003602

Identifiers

DOI

10.1101/GAD.1003602

1 reference

4 August 2017

1 reference