An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes (Q34733709)

4 August 2017

title

An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes (English)

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4 August 2017

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J Corral

1

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author name string

I Lavenir

2

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4 August 2017

H Impey

3

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A J Warren

4

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A Forster

5

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T A Larson

6

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S Bell

7

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A N McKenzie

8

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G King

9

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T H Rabbitts

10

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4 August 2017

language of work or name

English

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publication date

1 June 1996

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4 August 2017

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4 August 2017

volume

85

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4 August 2017

issue

6

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4 August 2017

page(s)

853-861

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Transgenic models of tumor development.

4 August 2017

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Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

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A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias

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Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product

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Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

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The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

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Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2

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Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases

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Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

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Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination

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Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs

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The der(11) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia

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A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.

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Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations

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Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

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Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

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Cre-mediated site-specific translocation between nonhomologous mouse chromosomes

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The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development

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Altered Hox expression and segmental identity in Mll-mutant mice

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Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

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Identifiers

DOI

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4 August 2017

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