PXR, CAR and drug metabolism (Q34743280)

4 August 2017

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title

PXR, CAR and drug metabolism (English)

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4 August 2017

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Timothy M Willson

1

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4 August 2017

Steven A Kliewer

series ordinal

2

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4 August 2017

publication date

1 April 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

volume

1

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4 August 2017

issue

4

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4 August 2017

page(s)

259-266

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P450 genes: structure, evolution, and regulation

4 August 2017

cites work

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P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

31 March 2020

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Xenobiotic-inducible transcription of cytochrome P450 genes.

31 March 2020

1 reference

31 March 2020

Hormones and resistance

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DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES

31 March 2020

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Phenobarbital induction of cytochrome P-450 gene expression

31 March 2020

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

31 March 2020

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Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

31 March 2020

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Enzyme induction in the cytochrome P-450 system

31 March 2020

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Cytochrome P-450 3A4: regulation and role in drug metabolism

31 March 2020

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Substrates of human hepatic cytochrome P450 3A4.

31 March 2020

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Adverse drug reactions and polypharmacy in the elderly in general practice

31 March 2020

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Clinical-pharmacological strategies to assess drug interaction potential during drug development

31 March 2020

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Orphan nuclear receptors: shifting endocrinology into reverse

31 March 2020

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Nuclear receptors and lipid physiology: opening the X-files

31 March 2020

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

31 March 2020

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The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

31 March 2020

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

31 March 2020

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

31 March 2020

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Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation

31 March 2020

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The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

31 March 2020

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CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

31 March 2020

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The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

31 March 2020

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

31 March 2020

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Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

31 March 2020

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Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

31 March 2020

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The nuclear receptor superfamily: the second decade

31 March 2020

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Steroid hormone receptors: many actors in search of a plot

31 March 2020

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St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

31 March 2020

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Pregnenolone-16 -carbonitrile: a new type of inducer of drug-metabolizing enzymes

31 March 2020

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

31 March 2020

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Humanized xenobiotic response in mice expressing nuclear receptor SXR.

31 March 2020

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Molecular mechanisms of cytochrome P-450 induction by xenobiotics: An expanded role for nuclear hormone receptors.

31 March 2020

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Induction of cytochromes P450.

31 March 2020

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Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes

31 March 2020

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The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

31 March 2020

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Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

31 March 2020

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The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

31 March 2020

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The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

31 March 2020

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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

31 March 2020

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Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

31 March 2020

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Role reversal: new insights from new ligands for the xenobiotic receptor CAR.

31 March 2020

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

31 March 2020

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Nuclear-receptor ligands and ligand-binding domains

31 March 2020

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Binding of ligands and activation of transcription by nuclear receptors.

31 March 2020

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The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

31 March 2020

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A canonical structure for the ligand-binding domain of nuclear receptors

31 March 2020

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The PXR ligand-binding domain: how to be picky and promiscuous at the same time.

31 March 2020

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The crystal structure of the nuclear receptor for vitamin D bound to its natural ligand

31 March 2020

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Use of the nuclear receptor PXR to predict drug interactions

31 March 2020

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Hepatic dysfunction associated with troglitazone

31 March 2020

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Troglitazone quinone formation catalyzed by human and rat CYP3A: an atypical CYP oxidation reaction

31 March 2020

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Induction of cytochrome P4503A by taxol in primary cultures of human hepatocytes

31 March 2020

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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

31 March 2020

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Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation.

31 March 2020

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Pregnane X receptor: molecular basis for species differences in CYP3A induction by xenobiotics

31 March 2020

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St John's wort, a herbal antidepressant, activates the steroid X receptor.

31 March 2020

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Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

31 March 2020

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

31 March 2020

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Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

31 March 2020

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Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

31 March 2020

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Pharmacogenetics and adverse drug reactions

31 March 2020

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Pharmacogenomics: the inherited basis for interindividual differences in drug response

31 March 2020

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A pharmacophore for human pregnane X receptor ligands

31 March 2020

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Structure-based library design: molecular modelling merges with combinatorial chemistry

31 March 2020

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The in silico world of virtual libraries

31 March 2020

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High throughput screening: early successes indicate a promising future

31 March 2020

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31 March 2020

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Transgenic xenosensors: humanizing mice

31 March 2020

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Peroxisome proliferator-activated receptor alpha controls the hepatic CYP4A induction adaptive response to starvation and diabetes

31 March 2020

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25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis

31 March 2020

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The promoter of the human 25-hydroxyvitamin D3 1 alpha-hydroxylase gene confers positive and negative responsiveness to PTH, calcitonin, and 1 alpha,25(OH)2D3.

31 March 2020

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

31 March 2020

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Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

31 March 2020

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Chemical genomics: functional analysis of orphan nuclear receptors in the regulation of bile acid metabolism

31 March 2020

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Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

31 March 2020

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Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways

31 March 2020

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Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

31 March 2020

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A family of drug transporters: the multidrug resistance-associated proteins.

31 March 2020

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Organic anion transport across the choroid plexus

31 March 2020

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ABC drug transporters: hereditary polymorphisms and pharmacological impact in MDR1, MRP1 and MRP2.

31 March 2020

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Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

31 March 2020

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The continuing importance of bile acids in liver and intestinal disease

31 March 2020

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A unified nomenclature system for the nuclear receptor superfamily

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD753

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4 August 2017

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