RNA interference: the new somatic cell genetics? (Q34768636)

4 August 2017

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title

RNA interference: the new somatic cell genetics? (English)

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4 August 2017

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2

Gregory J Hannon

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4 August 2017

Patrick J Paddison

1

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4 August 2017

publication date

1 July 2002

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4 August 2017

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4 August 2017

volume

2

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4 August 2017

issue

1

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4 August 2017

page(s)

17-23

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Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

4 August 2017

cites work

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7 January 2021

Role for a bidentate ribonuclease in the initiation step of RNA interference

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7 January 2021

Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines.

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7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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7 January 2021

Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

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7 January 2021

Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication

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7 January 2021

Reconstitution of transcription from the human U6 small nuclear RNA promoter with eight recombinant polypeptides and a partially purified RNA polymerase III complex

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7 January 2021

A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal

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7 January 2021

RNA interference in mammalian cells using siRNAs synthesized with T7 RNA polymerase

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7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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7 January 2021

Analysis of gene function in somatic mammalian cells using small interfering RNAs

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7 January 2021

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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7 January 2021

Induction of apoptosis by the dsRNA-dependent protein kinase (PKR): mechanism of action

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7 January 2021

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

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7 January 2021

The transcriptional start site for a human U6 small nuclear RNA gene is dictated by a compound promoter element consisting of the PSE and the TATA box

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7 January 2021

Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing

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7 January 2021

A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation

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7 January 2021

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

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7 January 2021

Post-transcriptional gene silencing by double-stranded RNA

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7 January 2021

MaRX: an approach to genetics in mammalian cells.

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7 January 2021

Genetic control of the cell division cycle in yeast

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7 January 2021

Checkpoints: controls that ensure the order of cell cycle events

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7 January 2021

Integrating genetic approaches into the discovery of anticancer drugs

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7 January 2021

A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells

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7 January 2021

Chalcone synthase cosuppression phenotypes in petunia flowers: comparison of sense vs. antisense constructs and single-copy vs. complex T-DNA sequences

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7 January 2021

Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans

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7 January 2021

Identification of novel genes coding for small expressed RNAs

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7 January 2021

An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans

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7 January 2021

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

An extensive class of small RNAs in Caenorhabditis elegans

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7 January 2021

Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

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7 January 2021

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Twist is a potential oncogene that inhibits apoptosis

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

U6 promoter-driven siRNAs with four uridine 3' overhangs efficiently suppress targeted gene expression in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

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7 January 2021

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

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7 January 2021

Cre recombinase: The universal reagent for genome tailoring

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7 January 2021

Molecular characterization of a mouse cDNA encoding Dicer, a ribonuclease III ortholog involved in RNA interference

1 reference

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7 January 2021

ATP requirements and small interfering RNA structure in the RNA interference pathway

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7 January 2021

Stable suppression of gene expression by RNAi in mammalian cells

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7 January 2021

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Effective expression of small interfering RNA in human cells

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Co-operative interaction between the initiator E1 and the transcriptional activator E2 is required for replicator specific DNA replication of bovine papillomavirus in vivo and in vitro.

1 reference

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7 January 2021

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

On the role of RNA amplification in dsRNA-triggered gene silencing

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Isolation of a transforming sequence from a human bladder carcinoma cell line

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

A DNA vector-based RNAi technology to suppress gene expression in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Targeted mRNA degradation by double-stranded RNA in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Specific interference with gene function by double-stranded RNA in early mouse development

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

High-efficiency identification of genes by functional analysis from a retroviral cDNA expression library

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells

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https://api.crossref.org/works/10.1016%2FS1535-6108%2802%2900092-2

7 January 2021

10.1016/S1535-6108(02)00092-2

Identifiers

DOI

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4 August 2017

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